Potential drug resistance polymorphisms in the integrase gene of HIV type 1 subtype A

被引:10
作者
Herring, BL
Cunningham, AL
Dwyer, DE
机构
[1] Westmead Hosp, Ctr Virus Res, Westmead Millennium Inst, Westmead, NSW 2145, Australia
[2] Westmead Hosp, Dept Virol, Ctr Infect Dis, Westmead, NSW 2145, Australia
[3] Westmead Hosp, Microbiol Lab Serv, ICPMR, Westmead, NSW 2145, Australia
关键词
D O I
10.1089/aid.2004.20.1010
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Variation in HIV-1 genes within and between subtypes has been best defined in the env gene, however, other more conserved genes vary between subtypes. Integrase ( IN) and other regions of the pol gene are highly conserved due to their integral role in HIV replication and therefore are targets for antiviral drugs. In this study 3 individuals, infected heterosexually with HIV-1 subtype A, were examined for IN polymorphisms. Two patients' sequences clustered phylogenetically with other subtype A sequences and one patient's sequence was most similar to the circulating recombinant form CRF_02. No polymorphisms were observed in either of the motifs containing residues critical residues for IN activity. Polymorphisms were observed in a residue associated with resistance to anti-integrase drugs. In addition, a number of unique polymorphisms were observed in one individual (WM1666). IN can vary significantly within a subtype as well as between subtypes, and mutations associated with resistance to anti-integrase compounds can be present in drug naive individuals.
引用
收藏
页码:1010 / 1014
页数:5
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