Phenotypic and Genotypic Characteristics of Inflammatory Bowel Disease in French Canadians: Comparison With a Large North American Repository

被引：24

作者：

Bhat, Mamatha ^{[1
]}

Nguyen, Geoffrey C. ^{[2
]}

Pare, Pierre ^{[3
]}

Lahaie, Raymond ^{[4
]}

Deslandres, Colette ^{[5
]}

Bernard, Edmond-Jean ^{[6
]}

Aumais, Guy ^{[7
]}

Jobin, Gilles ^{[7
]}

Wild, Gary ^{[8
]}

Cohen, Albert ^{[9
]}

Langelier, Diane ^{[10
]}

Brant, Steven ^{[11
]}

Dassopoulos, Themistocles ^{[11
]}

McGovern, Dermot ^{[12
,13
]}

Torres, Esther ^{[14
]}

Duerr, Richard ^{[15
,16
]}

Regueiro, Miguel ^{[15
,16
]}

Silverberg, Mark S. ^{[2
]}

Steinhart, Hillary ^{[2
]}

Griffiths, Anne M. ^{[2
]}

Elkadri, Abdul ^{[2
]}

Cho, Judy ^{[17
]}

Proctor, Deborah ^{[17
]}

Goyette, Philippe ^{[18
,19
]}

Rioux, John ^{[18
,19
]}

Bitton, Alain

机构：

[1] McGill Univ, Royal Victoria Hosp, Div Gastroenterol, Ctr Hlth, Montreal, PQ H3A 1A1, Canada

[2] Univ Toronto, Mt Sinai Hosp, Ctr Inflammatory Bowel Dis, Div Gastroenterol,Dept Med, Toronto, ON M5G 1X5, Canada

[3] Hop St Sacrement, Div Gastroenterol, Quebec City, PQ, Canada

[4] Univ Montreal, Hop St Luc, Div Gastroenterol, Ctr Hosp, Quebec City, PQ, Canada

[5] Hop St Justine, Div Gastroenterol, Montreal, PQ H3T 1C5, Canada

[6] Hop Hotel Dieu, Div Gastroenterol, Montreal, PQ H2W 1T8, Canada

[7] Hop Maison Neuve Rosemont, Div Gastroenterol, Montreal, PQ H1T 2M4, Canada

[8] McGill Univ, Montreal Gen Hosp, Div Gastroenterol, Quebec City, PQ, Canada

[9] McGill Univ, Jewish Gen Hosp, Div Gastroenterol, Montreal, PQ H3T 1E2, Canada

[10] CHU Sherbrooke, Div Gastroenterol, Sherbrooke, PQ J1H 5N4, Canada

[11] Johns Hopkins Univ, Sch Med, Harvey M & Lyn P Meyerhoff Inflammatory Bowel Dis, Div Gastroenterol,Dept Med, Baltimore, MD 21205 USA

[12] Cedars Sinai Med Ctr, Div Gastroenterol, Div Med Genet, Los Angeles, CA 90048 USA

[13] Cedars Sinai Med Ctr, Ctr Inflammatory Bowel Dis, Los Angeles, CA 90048 USA

[14] Univ Puerto Rico, Sch Med, Div Gastroenterol, Dept Med, San Juan, PR 00936 USA

[15] Univ Pittsburgh, Sch Med, Ctr Inflammatory Bowel Dis, Div Gastroenterol, Pittsburgh, PA USA

[16] Univ Pittsburgh, Sch Med, Div Gastroenterol Hepatol & Nutr, Pittsburgh, PA USA

[17] Yale Univ, Dept Med, Div Gastroenterol, Sect Digest Dis, New Haven, CT 06520 USA

[18] Univ Montreal, Quebec City, PQ, Canada

[19] Montreal Heart Inst, Quebec City, PQ, Canada

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 2009年 / 104卷 / 09期

关键词：

GENOME-WIDE ASSOCIATION; CROHNS-DISEASE; POPULATION; SMOKING; QUEBEC; MANIFESTATIONS; CLASSIFICATION; GENETICS; METAANALYSIS; PREVALENCE;

D O I：

10.1038/ajg.2009.267

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

OBJECTIVES: Phenotype characteristics of inflammatory bowel disease (IBD) may differ significantly among ethnic subpopulations. The aim of this study was to characterize the IBD phenotype in French Canadians, the most prominent founder population in North America. METHODS: Using well-characterized phenotype data in the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)-IBD Genetics Consortium repository on patients with IBD, we compared phenotypic characteristics of 202 French Canadians with those of 1,287 other Caucasian patients. These included diagnosis, anatomical location, disease behavior, extraintestinal manifestations, surgical history, and family history of IBD. RESULTS: French-Canadian patients with Crohn's disease (CD) were less likely to have stricturing disease (11 vs. 21 %, P = 0.005; odds ratio (OR): 0.45, 95 % confidence interval (95 % CI): 0.24-0.85). Using a stringent definition of ethnicity (three out of four grandparents being French Canadians, as opposed to self-report, n = 148), French Canadians had a tendency toward developing fistulizing CD (37 vs. 28 %, P = 0.07), and there was an increased prevalence of sacroiliitis among those with IBD (4 vs. 2 %, P = 0.045). Among French Canadians, the numbers of current smokers in CD (40 vs. 25 %, P = 0.006) and former smokers in ulcerative colitis (UC) (35 vs. 20 %, P = 0.03) were significantly higher. The prevalence of one of the three main variants of nucleotide-binding oligomerization domain containing 2 (NOD2) single-nucleotide polymorphisms (SNPs)-among French-Canadian CD patients was 43.2 %. The 3020insC SNP correlated with small bowel disease in French Canadians (75 vs. 0 %, P = 0.006). CONCLUSIONS: French Canadians show an IBD phenotype profile distinct from other Caucasian IBD populations, with an accentuated association between smoking status and IBD. This unique profile may have implications regarding the need for a different approach to the management of IBD in this population.

引用

页码：2233 / 2240

页数：8

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