Novel variant (blaVlM-4) of the metallo-β-lactamase gene blaVIM-1 in a clinical strain of Pseudomonas aeruginosa

被引：71

作者：

Pournaras, S

Tsakris, A

Maniati, M

Tzouvelekis, LS

Maniatis, AN

机构：

[1] Univ Thessaly, Dept Med Microbiol, Larisa 41222, Greece

[2] Univ Thessaly, Sch Med, Dept Microbiol, Thessaloniki, Greece

[3] Univ Athens, Sch Med, Dept Microbiol, GR-11527 Athens, Greece

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 12期

关键词：

D O I：

10.1128/AAC.46.12.4026-4028.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A Pseudomonas aeruginosa isolate highly resistant to carbapenems was collected from a patient with post-surgical cerebrospinal infection in Greece. The isolate carried a class I integron that contained as a sole cassette the gene bla(VIM-4), a novel variant of bla(VIM-1), with one nucleotide difference resulting in a Ser-to-Arg change at amino acid position 175 of the VIM-1 enzyme. This is the first detection of a VIM-1 variant after its appearance in Italy.

引用

收藏

页码：4026 / 4028

页数：3

相关论文

共 19 条

[1] Hospital outbreak of carbapenem-resistant Pseudomonas aeruginosa producing VIM-1, a novel transferable metallo-β-lactamase [J].

Cornaglia, G ;

Mazzariol, A ;

Lauretti, L ;

Rossolini, GM ;

Fontana, R .

CLINICAL INFECTIOUS DISEASES, 2000, 31 (05) :1119-1125

[2] Purification and biochemical characterization of the VIM-1 metallo-β-lactamase [J].

Franceschini, N ;

Caravelli, B ;

Docquier, JD ;

Galleni, M ;

Frère, JM ;

Amicosante, G ;

Rossolini, GM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (11) :3003-3007

[3] Standard numbering scheme for class B β-lactamases [J].

Galleni, M ;

Lamotte-Brasseur, J ;

Rossolini, GM ;

Spencer, J ;

Dideberg, O ;

Frère, JM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (03) :660-663

[4] Cloning and characterization of blaVIM, a new integron-borne metallo-β-lactamase gene from a Pseudomonas aeruginosa clinical isolate [J].

Lauretti, L ;

Riccio, ML ;

Mazzariol, A ;

Cornaglia, G ;

Amicosante, G ;

Fontana, R ;

Rossolini, GM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (07) :1584-1590

[5] blaVIM-2 Cassette-containing novel integrons in metallo-β-lactamase-producing Pseudomonas aeruginosa and Pseudomonas putida isolates disseminated in a Korean hospital [J].

Lee, K ;

Lim, JB ;

Yum, JH ;

Yong, DG ;

Chong, YS ;

Kim, JM ;

Livermore, DM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (04) :1053-1058

[6] PCR MAPPING OF INTEGRONS REVEALS SEVERAL NOVEL COMBINATIONS OF RESISTANCE GENES [J].

LEVESQUE, C ;

PICHE, L ;

LAROSE, C ;

ROY, PH .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (01) :185-191

[7] Carbapenemases: a problem in waiting? [J].

Livermore, DM ;

Woodford, N .

CURRENT OPINION IN MICROBIOLOGY, 2000, 3 (05) :489-495

[8] Carbapenem-hydrolysing VIM-2 metallo-β-lactamase in Pseudomonas aeruginosa from Greece [J].

Mavroidi, A ;

Tsakris, A ;

Tzelepi, E ;

Pournaras, S ;

Loukova, V ;

Tzouvelekis, LS .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2000, 46 (06) :1041-1043

[9]

*NAT COMM CLIN LAB, 1999, M7A5 NAT COMM CLIN L

[10]

National Committee for Clinical Laboratory Standards, 2001, M2A7 NAT COMM CLIN L