Hexose-6-phosphate dehydrogenase: linking endocrinology and metabolism in the endoplasmic reticulum

被引：33

作者：

Banhegyi, Gabor ^{[1
,2
,3
]}

Csala, Miklos ^{[2
,3
]}

Benedetti, Angelo ^{[1
]}

机构：

[1] Univ Siena, Dipartimento Fisiopatol Med Sperimentale & Sanita, I-53100 Siena, Italy

[2] Semmelweis Univ, Dept Med Chem Mol Biol & Pathobiochem, H-1444 Budapest, Hungary

[3] MTA SE Pathobiochem Res Grp, H-1444 Budapest, Hungary

来源：

JOURNAL OF MOLECULAR ENDOCRINOLOGY | 2009年 / 42卷 / 3-4期

关键词：

PITUITARY-ADRENAL AXIS; FATTY-ACID CYCLE; 11-BETA-HYDROXYSTEROID DEHYDROGENASE; ADIPOSE-TISSUE; PYRIDINE-NUCLEOTIDES; NADPH/NADP(+) RATIO; PANCREATIC-ISLETS; TYPE-1; ACTIVITY; ER STRESS; GLUCOSE;

D O I：

10.1677/JME-08-0156

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Hexose-6-phosphate dehydrogenase (H6PD) got into the focus of interest due to its role in the prereceptorial activation of glucocorticoids, which has been implicated in the pathomechanism of metabolic syndrome. Genetic observations, results gained in H6PD knockout mice, and studies on differentiating adipocytes demonstrated the importance of the enzyme in metabolic regulation. A nutrient-sensing function can be postulated for the enzyme, which links metabolism to endocrinology in the endoplasmic reticulum. This review provides an overview of the recent developments concerning the enzyme and its impact on various branches of the intermediary metabolism, which make it an important subject for the research on obesity, diabetes, and metabolic syndrome. Journal of Molecular Endocrinology (2009) 42, 283-289

引用

页码：283 / 289

页数：7

共 67 条

[1]

Hexose-6-phosphate dehydrogenase determines the reaction direction of 11β-hydroxysteroid dehydrogenase type 1 as an oxoreductase [J].