New developments of brain imaging for Parkinson's disease and related disorders

被引：30

作者：

Piccini, Paola

Brooks, David J.

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, MRC, Ctr Clin Sci,Fac Med, London W12 0NN, England

[2] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Div Neurosci & Mental Hlth, London W12 0NN, England

来源：

MOVEMENT DISORDERS | 2006年 / 21卷 / 12期

基金：

英国医学研究理事会;

关键词：

functional imaging; Parkinson's disease; movement disorders;

D O I：

10.1002/mds.20845

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Parkinson's disease (PD) and related disorders are subcortical degenerations targeting the nigrostriatal dopaminergic system and basal ganglia. Traditionally, MRI has been used to detect structural and positron emission tomography and single emission computed tomography functional neurochemical and metabolic changes associated with these disorders. Recently, advances in diffusion-weighted MRI, ultrasonography, and radiotracer-based imaging have yielded greater sensitivity for revealing structural change and allowed detection of changes in brain dopamine levels after levodopa and during behavioral tasks. This review focuses on these recent advances in neuroimaging technology and their use for the diagnosis and assessment of PD and other parkinsonian disorders. (C) 2006 Movement Disorder Society.

引用

页码：2035 / 2041

页数：7

共 43 条

[1] Differentiation of Parkinson's disease and atypical parkinsonian syndromes by transcranial ultrasound [J].

Behnke, S ;

Berg, D ;

Naumann, M ;

Becker, G .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2005, 76 (03) :423-425

[2] Five-year follow-up study of hyperechogenicity of the substantia nigra in Parkinson's disease [J].

Berg, D ;

Metz, B ;

Reiners, K ;

Naumann, M ;

Becker, G .

MOVEMENT DISORDERS, 2005, 20 (03) :383-385

[3] Echogenicity of the substantia nigra -: Association with increased iron content and marker for susceptibility to nigrostriatal injury [J].

Berg, D ;

Roggendorf, W ;

Schröder, U ;

Klein, R ;

Tatschner, T ;

Benz, P ;

Tucha, O ;

Preier, M ;

Lange, KW ;

Reiners, K ;

Gerlach, M ;

Becker, G .

ARCHIVES OF NEUROLOGY, 2002, 59 (06) :999-1005

[4] Echogenicity of the substantia nigra in Parkinsons disease and its relation to clinical findings [J].

Berg, D ;

Siefker, C ;

Becker, G .

JOURNAL OF NEUROLOGY, 2001, 248 (08) :684-689

[5] Relationship of substantia nigra echogenicity and motor function in elderly subjects [J].

Berg, D ;

Siefker, C ;

Ruprecht-Dörfler, P ;

Becker, G .

NEUROLOGY, 2001, 56 (01) :13-17

[6] Vulnerability of the nigrostriatal system as detected by transcranial ultrasound [J].

Berg, D ;

Becker, G ;

Zeiler, B ;

Tucha, O ;

Hofmann, E ;

Preier, M ;

Benz, P ;

Jost, W ;

Reiners, K ;

Lange, KW .

NEUROLOGY, 1999, 53 (05) :1026-1031

[7] Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method [J].

Breier, A ;

Su, TP ;

Saunders, R ;

Carson, RE ;

Kolachana, BS ;

de Bartolomeis, A ;

Weinberger, DR ;

Weisenfeld, N ;

Malhotra, AK ;

Eckelman, WC ;

Pickar, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (06) :2569-2574

[8]

BROOKS DJ, 1992, ADV NEUROL, V58, P227

[9] Quantification of amphetamine-induced changes in [C-11]raclopride binding with continuous infusion [J].

Carson, RE ;

Breier, A ;

deBartolomeis, A ;

Saunders, RC ;

Su, TP ;

Schmall, B ;

Der, MG ;

Pickar, D ;

Eckelman, WC .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1997, 17 (04) :437-447

[10] INVIVO [H-3]SPIPERONE BINDING - EVIDENCE FOR ACCUMULATION IN CORPUS STRIATUM BY AGONIST-MEDIATED RECEPTOR INTERNALIZATION [J].

CHUGANI, DC ;

ACKERMANN, RF ;

PHELPS, ME .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1988, 8 (03) :291-303

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