Pharmacokinetics and pharmacodynamics of gatifloxacin against Streptococcus pneumoniae and Staphylococcus aureus in a granulocyte-rich exudate

被引：7

作者：

Trampuz, A

Laifer, G

Wenk, M

Rajacic, Z

Zimmerli, W

机构：

[1] Univ Med Ctr, CH-4410 Liestal, Switzerland

[2] Univ Basel Hosp, Div Infect Dis, CH-4031 Basel, Switzerland

[3] Univ Basel Hosp, Div Clin Pharmacol, CH-4031 Basel, Switzerland

[4] Univ Basel Hosp, Dept Internal Med, CH-4031 Basel, Switzerland

[5] Univ Basel Hosp, Dept Res, CH-4031 Basel, Switzerland

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 11期

关键词：

D O I：

10.1128/AAC.46.11.3630-3633.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The pharmacokinetics of gatifloxacin were assessed in serum and in skin blister fluid (SBF), as was the pharmacodynamic activity in SBF. Five hours after a single dose of gatifloxacin, SBF killed 2.5 logs of Streptococcus pneumoniae and 1.5 log of Staphylococcus aureus during a 2-h incubation ex vivo.

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页码：3630 / 3633

页数：4

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