Microarray data normalization and transformation

被引：1294

作者：

Quackenbush, J ^{[1
]}

机构：

[1] Inst Genom Res, Rockville, MD 20850 USA

来源：

NATURE GENETICS | 2002年 / 32卷 / Suppl 4期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1038/ng1032

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Underlying every microarray experiment is an experimental question that one would like to address. Finding a useful and satisfactory answer relies on careful experimental design and the use of a variety of data-mining tools to explore the relationships between genes or reveal patterns of expression. While other sections of this issue deal with these lofty issues, this review focuses on the much more mundane but indispensable tasks of 'normalizing' data from individual hybridizations to make meaningful comparisons of expression levels, and of 'transforming' them to select genes for further analysis and data mining.

引用

页码：496 / 501

页数：6

共 16 条

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