Gastrointestinal satiety signals in humans - Physiologic roles for GLP-1 and PYY ?

被引:88
作者
Beglinger, Christoph [1 ]
Degen, Lukas [1 ]
机构
[1] Univ Basel Hosp, Div Gastroenterol, CH-4031 Basel, Switzerland
关键词
PYY; GLP-1; appetite control; human studies;
D O I
10.1016/j.physbeh.2006.05.048
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
The present review summarizes the appetite suppressing effects of PYY and GLP-1 in the regulation of food intake in humans. Current evidence supports a role for gastrointestinal peptides as regulators of satiety. The regulation of satiety is, however, complex and it is not surprising that multiple control systems exist. It is interesting to note that nutrients in the small intestine such as hydrolysis products of fat stimulate the release of satiety peptides such as GLP-1 or PYY that serve as satiety signals. Both peptides, released from L-cells from the gastrointestinal tract by the local action of digested food, exert various regulatory functions: stimulation of insulin secretion and inhibition of glucagon secretion as typical actions of GLP-1, inhibition of gastric emptying, and inhibition of appetite for both GLP-1 and PYY. The review focuses on the question, whether the two peptides are true endocrine factors that act as physiologic, hormonal regulators of appetite. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:460 / 464
页数:5
相关论文
共 40 条
  • [1] HUMAN DISTRIBUTION AND RELEASE OF A PUTATIVE NEW GUT HORMONE, PEPTIDE-YY
    ADRIAN, TE
    FERRI, GL
    BACARESEHAMILTON, AJ
    FUESSL, HS
    POLAK, JM
    BLOOM, SR
    [J]. GASTROENTEROLOGY, 1985, 89 (05) : 1070 - 1077
  • [2] Gut hormone PYY3-36 physiologically inhibits food intake
    Batterham, RL
    Cowley, MA
    Small, CJ
    Herzog, H
    Cohen, MA
    Dakin, CL
    Wren, AM
    Brynes, AE
    Low, MJ
    Ghatei, MA
    Cone, RD
    Bloom, SR
    [J]. NATURE, 2002, 418 (6898) : 650 - 654
  • [3] Inhibition of food intake in obese subjects by peptide YY3-36
    Batterham, RL
    Cohen, MA
    Ellis, SM
    Le Roux, CW
    Withers, DJ
    Frost, GS
    Ghatei, MA
    Bloom, SR
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (10) : 941 - 948
  • [4] Loxiglumide, a CCK-A receptor antagonist, stimulates calorie intake and hunger feelings in humans
    Beglinger, C
    Degen, L
    Matzinger, D
    D'Amato, M
    Drewe, J
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2001, 280 (04) : R1149 - R1154
  • [5] Control of human appetite: Implications for the intake of dietary fat
    Blundell, JE
    Lawton, CL
    Cotton, JR
    Macdiarmid, JI
    [J]. ANNUAL REVIEW OF NUTRITION, 1996, 16 : 285 - 319
  • [6] Gastric emptying, gastric secretion and enterogastrone response after administration of milk proteins or their peptide hydrolysates in humans
    Calbet, JAL
    Holst, JJ
    [J]. EUROPEAN JOURNAL OF NUTRITION, 2004, 43 (03) : 127 - 139
  • [7] Effect of chronic central administration of glucagon-like peptide-1 (7-36) amide on food consumption and body weight in normal and obese rats
    Davis, HR
    Mullins, DE
    Pines, JM
    Hoos, LM
    France, CF
    Compton, DS
    Graziano, MP
    Sybertz, EF
    Strader, CD
    Van Heek, M
    [J]. OBESITY RESEARCH, 1998, 6 (02): : 147 - 156
  • [8] Effect of peptide YY3-36 on food intake in humans
    Degen, L
    Oesch, S
    Casanova, M
    Graf, S
    Ketterer, S
    Drewe, J
    Beglinger, C
    [J]. GASTROENTEROLOGY, 2005, 129 (05) : 1430 - 1436
  • [9] Dillon JS, 1997, ADV EXP MED BIOL, V426, P113
  • [10] GLUCAGON-LIKE PEPTIDE-1(7-36)AMIDE AND GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE SECRETION IN RESPONSE TO NUTRIENT INGESTION IN MAN - ACUTE POSTPRANDIAL AND 24-H SECRETION PATTERNS
    ELLIOTT, RM
    MORGAN, LM
    TREDGER, JA
    DEACON, S
    WRIGHT, J
    MARKS, V
    [J]. JOURNAL OF ENDOCRINOLOGY, 1993, 138 (01) : 159 - 166