Small-Molecule-Dependent Regulation of Transfer RNA in Bacteria

被引：30

作者：

Berschneider, Barbara ^{[1
,2
]}

Wieland, Markus ^{[1
,2
]}

Rubini, Marina ^{[1
,2
]}

Hartig, Joerg S. ^{[1
,2
]}

机构：

[1] Univ Konstanz, Dept Chem, D-78457 Constance, Germany

[2] Univ Konstanz, Konstanz Res Sch Chem Biol, D-78457 Constance, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 41期

关键词：

genetic code; hammerhead ribozymes; molecular switches; RNA; translation; GENE-EXPRESSION; ESCHERICHIA-COLI; RIBOZYME; RIBOSWITCHES; CODE; CATALYSIS; CLEAVAGE; DOMAINS;

D O I：

10.1002/anie.200900851

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

External influence: Transfer RNA can be regulated by fusing a ligand-dependent ribozyme to the tRNA, resulting in disruption of the functional tRNA structure. Upon smallmolecule- dependent activation of ribozyme cleavage, the tRNA is released and can be processed to act in translation. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

收藏

页码：7564 / 7567

页数：4

相关论文

共 29 条

[1]

Prolegomena to future experimental efforts on genetic code engineering by expanding its amino acid repertoire [J].

Budisa, N .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (47) :6426-6463

[2]

POLYPEPTIDE CHAIN TERMINATION IN VITRO - ISOLATION OF A RELEASE FACTOR [J].

CAPECCHI, MR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1967, 58 (03) :1144-&

[3]

Polyadenylation of rRNA- and tRNA-based yeast transcripts cleaved by internal ribozyme activity [J].

Düvel, K ;

Pries, R ;

Braus, GH .

CURRENT GENETICS, 2003, 43 (04) :255-262

[4]

tRNA transfers to the limelight [J].

Hopper, AK ;

Phizicky, EM .

GENES & DEVELOPMENT, 2003, 17 (02) :162-180

[5]

Sequence elements outside the hammerhead ribozyme catalytic core enable intracellular activity [J].

Khvorova, A ;

Lescoute, A ;

Westhof, E ;

Jayasena, SD .

NATURE STRUCTURAL BIOLOGY, 2003, 10 (09) :708-712

[6]

RNase P RNA mediated cleavage: Substrate recognition and catalysis [J].

Kirsebom, Leif A. .

BIOCHIMIE, 2007, 89 (10) :1183-1194

[7]

3′ exoribonucleolytic trimming is a common feature of the maturation of small, stable RNAs in Escherichia coli [J].

Li, ZW ;

Pandit, S ;

Deutscher, MP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (06) :2856-2861

[8]

RNA quality control: degradation of defective transfer RNA [J].

Li, ZW ;

Reimers, S ;

Pandit, S ;

Deutscher, MP .

EMBO JOURNAL, 2002, 21 (05) :1132-1138

[9]

Non-canonical amino acids in protein engineering [J].

Link, AJ ;

Mock, ML ;

Tirrell, DA .

CURRENT OPINION IN BIOTECHNOLOGY, 2003, 14 (06) :603-609

[10]

Tertiary contacts distant from the active site prime a ribozyme for catalysis [J].

Martick, Monika ;

Scott, William G. .

CELL, 2006, 126 (02) :309-320