Quality control in the endoplasmic reticulum protein factory

被引：563

作者：

Sitia, R ^{[1
]}

Braakman, I

机构：

[1] Univ Vita Salute, San Raffaele Sci Inst, I-20132 Milan, Italy

[2] Univ Utrecht, NL-3584 CH Utrecht, Netherlands

来源：

NATURE | 2003年 / 426卷 / 6968期

关键词：

D O I：

10.1038/nature02262

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The endoplasmic reticulum (ER) is a factory where secretory proteins are manufactured, and where stringent quality-control systems ensure that only correctly folded proteins are sent to their final destinations. The changing needs of the ER factory are monitored by integrated signalling pathways that constantly adjust the levels of folding assistants. ER chaperones and signalling molecules are emerging as drug targets in amyloidoses and other protein-conformational diseases.

引用

页码：891 / 894

页数：4

共 42 条

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