Molecular cloning and characterization of a novel SH3 protein (SLY) preferentially expressed in lymphoid cells

被引：28

作者：

Beer, S

Simins, AB

Schuster, A

Holzmann, B

机构：

[1] Tech Univ Munich, Inst Med Microbiol & Hyg, D-81675 Munich, Germany

[2] Tech Univ Munich, Dept Surg, D-81675 Munich, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 2001年 / 1520卷 / 01期

关键词：

signaling adaptor protein; Src homology 3 domain; lymphatic expression; X-chromosome;

D O I：

10.1016/S0167-4781(01)00242-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel full-length cDNA was isolated from a murine T-cell lymphoma library that has an open reading frame encoding 381 amino acids. The predicted protein (termed SLY) contains a Src homology 3 domain and a sterile a motif, suggesting that it functions as a signaling adaptor protein in lymphocytes. Northern blot and in situ hybridization analysis showed a preferential expression in lymphoid tissues. The sly gene is located on the X-chromosome in close proximity to genes involved in various immune disorders. This is consistent with an additional role of SLY in immune pathology. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：89 / 93

页数：5

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