Increased salivary cortisol after waking in depression

被引:217
作者
Bhagwagar, Z [1 ]
Hafizi, S [1 ]
Cowen, PJ [1 ]
机构
[1] Univ Oxford, Dept Psychiat, Warneford Hosp, Oxford OX3 7JX, England
基金
英国医学研究理事会;
关键词
cortisol; depression; waking;
D O I
10.1007/s00213-005-0062-z
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Rationale: Cortisol hypersecretion is regarded as important in the pathophysiology of major depression. However, recent studies in community-based samples have been inconclusive. Objective: To determine whether acutely depressed, medication-free subjects show an exaggerated release of cortisol in saliva in relation to awakening. Methods: We studied the pattern of waking salivary cortisol in 20 unmedicated acutely depressed subjects and 40 healthy controls. Results: In both groups, salivary cortisol increased rapidly after waking, peaking at 30 min. Overall, patients with acute depression secreted approximately 25% more cortisol than controls, though 60 min after waking, their cortisol levels were similar. Conclusions: Depressed patients in the community appear to have increased early morning cortisol secretion, but the demonstration of this effect requires control for time of waking.
引用
收藏
页码:54 / 57
页数:4
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