Oocyte cryopreservation in a patient with sickle cell disease prior to hematopoietic stem cell transplantation: first report

被引：19

作者：

Dovey, Serena ^{[1
]}

Krishnamurti, Lakshmanan ^{[2
]}

Sanfilippo, Joseph ^{[1
]}

Gunawardena, Sriya ^{[2
]}

Mclendon, Patricia ^{[2
]}

Campbell, Mary ^{[2
]}

Alway, Sandra ^{[1
]}

Efymow, Brenda ^{[3
]}

Gracia, Clarisa ^{[3
]}

机构：

[1] Univ Pittsburgh, Magee Womens Hosp, Med Ctr, Div Obstet Gynecol & Reprod Sci, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Childrens Hosp Pittsburgh, Med Ctr, Div Pediat Hematol Oncol, Pittsburgh, PA 15224 USA

[3] Univ Penn, Med Ctr, Dept Obstet & Gynecol, Penn Fertil Care, Philadelphia, PA 19104 USA

来源：

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | 2012年 / 29卷 / 03期

关键词：

Sickle cell disease; Fertility preservation; Oocyte cryopreservation; Controlled ovarian stimulation; Hematopoietic stem cell transplantation; BONE-MARROW-TRANSPLANTATION; OVARIAN HYPERSTIMULATION SYNDROME; THROMBOTIC COMPLICATIONS; GONADAL-FUNCTION; PULMONARY; RISK; HYPERCOAGULABILITY; FERTILITY; AGONIST; ANEMIA;

D O I：

10.1007/s10815-011-9698-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

To report the first occurrence of successful ovarian stimulation, oocyte retrieval and oocyte cryopreservation for fertility preservation in an adolescent with severe sickle cell disease scheduled to undergo a hematopoietic stem cell transplant Case report A 19 year old female with severe sickle cell disease presented for fertility preservation counseling prior to hematopoietic stem cell transplantation. She ultimately underwent ovarian stimulation using a minimal stimulation GnRH antagonist protocol resulting in the successful banking of oocytes prior to transplant. The unique hazards associated with ovarian stimulation in patients with sickle cell disease, such as thrombosis and vaso-occlusive events, are discussed and the methods undertaken to minimize these risks are described. Controlled ovarian hyperstimulation and oocyte banking for fertility preservation is feasible in young women with sickle cell disease requiring hematopoietic stem cell transplant and deserves further investigation. Given the elevated risk of thrombosis and predisposition to painful vaso-occlusive events, controlled ovarian hyperstimulation in patients with sickle cell disease is not straightforward and requires a multi-disciplinary team approach to adequately address and minimize the risks in this unique patient population.

引用

页码：265 / 269

页数：5

共 39 条

[1] Hematopoietic Stem-Cell Transplantation for Adults with Sickle Cell Disease. [J].