Age-related effects on genital reflexes induced by paradoxical sleep deprivation and cocaine in rats

被引:19
作者
Andersen, ML [1 ]
Bignotto, M [1 ]
Papale, LA [1 ]
Tufik, S [1 ]
机构
[1] Univ Fed Sao Paulo, Dept Psychobiol, Escola Paulista Med, BR-04024002 Sao Paulo, Brazil
基金
巴西圣保罗研究基金会;
关键词
sleep deprivation; aging; sexual behavior; cocaine; dopamine; penile erection; male rat;
D O I
10.1016/j.exger.2003.10.026
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Although sexual function often decreases with age, a recent study demonstrated that paradoxical sleep deprivation (PSD) was effective in inducing penile erection (PE) in 60% of 22-month-old PSD rats after acute cocaine injection, whereas this behavior was absent in non-PSD control rats. The present study sought to compare alterations in genital reflexes (PE and ejaculation-EJ) induced by PSD followed by acute cocaine or saline at different points in the life span of male rats. Rats of different ages (3, 6, 10, 12, 18, 22 and 28 months), were given a single injection of either saline or cocaine (7 mg/kg, i.p.) after a 4-day period of PSD, and then evaluated for genital reflexes. Results indicated that genital reflexes in PSD rats given saline become less frequent with age and disappear after the age of 18 months. However, cocaine potentiated and prolonged these behaviors until the age of 22 months. Although a number of factors are involved in such a complex phenomenon as PE, we suggest that the previously documented dopamine receptor supersensitivity induced by PSD may be an important contributor to the potentiation by cocaine of genital reflexes after sleep deprivation. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码:233 / 237
页数:5
相关论文
共 20 条
  • [1] The effect of apomorphine on genital reflexes in male rats deprived of paradoxical sleep
    Andersen, ML
    Bignotto, M
    Tufik, S
    [J]. PHYSIOLOGY & BEHAVIOR, 2003, 80 (2-3) : 211 - 215
  • [2] Facilitation of ejaculation after methamphetamine administration in paradoxical sleep deprived rats
    Andersen, ML
    Bignotto, M
    Tufik, S
    [J]. BRAIN RESEARCH, 2003, 978 (1-2) : 31 - 37
  • [3] Influence of paradoxical sleep deprivation and cocaine on development of spontaneous penile reflexes in rats of different ages
    Andersen, ML
    Bignotto, M
    Tutik, S
    [J]. BRAIN RESEARCH, 2003, 968 (01) : 130 - 138
  • [4] Cocaine-induced genital reflexes during paradoxical sleep deprivation and recovery
    Andersen, ML
    Bignotto, M
    Tufik, S
    [J]. PHYSIOLOGY & BEHAVIOR, 2003, 78 (02) : 255 - 259
  • [5] Does paradoxical sleep deprivation and cocaine induce penile erection and ejaculation in old rats?
    Andersen, ML
    Bignotto, M
    Machado, RB
    Tufik, S
    [J]. ADDICTION BIOLOGY, 2002, 7 (03) : 285 - 290
  • [6] Distinct effects of paradoxical sleep deprivation and cocaine administration on sexual behavior in male rats
    Andersen, ML
    Tufik, S
    [J]. ADDICTION BIOLOGY, 2002, 7 (02) : 251 - 253
  • [7] The effects of acute cocaine administration in paradoxical sleep-deprived rats
    Andersen, ML
    Palma, BD
    Rueda, AD
    Tufik, S
    [J]. ADDICTION BIOLOGY, 2000, 5 (04) : 417 - 420
  • [8] Age decreases nitric oxide synthase-containing nerve fibers in the rat penis
    Carrier, S
    Nagaraju, P
    Morgan, DM
    Baba, K
    Nunes, L
    Lue, TF
    [J]. JOURNAL OF UROLOGY, 1997, 157 (03) : 1088 - 1092
  • [9] Nitric oxide as a mediator of cocaine-induced penile erection in the rat
    Chan, JYH
    Huang, CL
    Chan, SHH
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1996, 118 (01) : 155 - 161
  • [10] GARBAN H, 1995, AM J PHYSIOL, V268, P467