High serum interleukin-10 and tumor necrosis factor alpha levels in chronic paracoccidioidomycosis

被引：21

作者：

Fornari, MC

Bava, AJ

Guereño, MT

Berardi, VE

Silaf, MR

Negroni, R

Diez, RA

机构：

[1] Univ Buenos Aires, Fac Med, Sch Med, Dept Pharmacol,Lab Inmunofarmacol, RA-1121 Buenos Aires, DF, Argentina

[2] Acad Nacl Med Buenos Aires, Buenos Aires, DF, Argentina

[3] Hosp Muniz, Buenos Aires, DF, Argentina

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 2001年 / 8卷 / 05期

关键词：

D O I：

10.1128/CDLI.8.5.1036-1038.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In patients with chronic paracoccidioidomycosis (n = 10), levels of tumor necrosis factor alpha, interleukin-10, and interleukin-2 in serum, measured by enzyme-linked immunosorbent assay (in picograms per milliliter, as mean +/- standard error of the mean), were higher than in normal controls (n = 8): 186 +/- 40 versus 40 +/- 7 (P < 0.05), 203 +/- 95 versus 20 +/- 8 (P = 0.001), and 96.3 +/- 78.57 versus 1.19 +/- 1.19 (P = 0.045), respectively. Gamma interferon and interleukin-4 levels were similar in patients and controls.

引用

页码：1036 / 1038

页数：3

共 13 条

[1] LYMPHOCYTE SUBPOPULATIONS AND CYTOKINE PRODUCTION IN PARACOCCIDIOIDOMYCOSIS PATIENTS [J].

BAVA, AJ ;

MISTCHENKO, AS ;

PALACIOS, MF ;

ESTEVEZ, ME ;

TIRABOSCHI, NI ;

SEN, L ;

NEGRONI, R ;

DIEZ, RA .

MICROBIOLOGY AND IMMUNOLOGY, 1991, 35 (03) :167-174

[2] Imbalance of IL-2, IFN-γ and IL-10 secretion in the immunosuppression associated with human paracoccidioidomycosis [J].

Benard, G ;

Romano, CC ;

Cacere, CR ;

Juvenale, M ;

Mendes-Giannini, MJS ;

Duarte, AJS .

CYTOKINE, 2001, 13 (04) :248-252

[3] Cytokines produced by susceptible and resistant mice in the course of Paracoccidioides brasiliensis infection [J].

Calich, VLG ;

Kashino, SS .

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 1998, 31 (05) :615-623

[4] Protective role of gamma interferon in experimental pulmonary paracoccidioidomycosis [J].

Cano, LE ;

Kashino, SS ;

Arruda, C ;

André, D ;

Xidieh, CF ;

Singer-Vermes, LM ;

Vaz, CAC ;

Burger, E ;

Calich, VLG .

INFECTION AND IMMUNITY, 1998, 66 (02) :800-806

[5] INTERLEUKIN-10 (IL-10) INHIBITS HUMAN LYMPHOCYTE INTERFERON GAMMA-PRODUCTION BY SUPPRESSING NATURAL-KILLER-CELL STIMULATORY FACTOR/IL-12 SYNTHESIS IN ACCESSORY CELLS [J].

DANDREA, A ;

ASTEAMEZAGA, M ;

VALIANTE, NM ;

MA, XJ ;

KUBIN, M ;

TRINCHIERI, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (03) :1041-1048

[6] Pattern of immune response to GP43 from Paracoccidioides brasiliensis in susceptible and resistant mice is influenced by antigen-presenting cells [J].

de Almeida, SR ;

de Moraes, JZ ;

de Camargo, ZP ;

Gesztesi, JL ;

Mariano, M ;

Lopes, JD .

CELLULAR IMMUNOLOGY, 1998, 190 (01) :68-76

[7] Interleukin-10 does not affect phagocytosis of particulate antigen by bonemarrow-derived dendritic cells but does impair antigen presentation [J].

Faulkner, L ;

Buchan, G ;

Baird, M .

IMMUNOLOGY, 2000, 99 (04) :523-531

[8] Production of IFN-γ is impaired in patients with paracoccidioidomycosis during active disease and is restored after clinical remission [J].

Karhawi, ASK ;

Colombo, AL ;

Salomao, R .

MEDICAL MYCOLOGY, 2000, 38 (03) :225-229

[9] INTERLEUKIN-12 SYNERGIZES WITH B7/CD28 INTERACTION IN INDUCING EFFICIENT PROLIFERATION AND CYTOKINE PRODUCTION OF HUMAN T-CELLS [J].

KUBIN, M ;

KAMOUN, M ;

TRINCHIERI, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (01) :211-222

[10] CORRELATION BETWEEN CELL-MEDIATED-IMMUNITY AND CLINICAL FORMS OF PARACOCCIDIOIDOMYCOSIS [J].

MOTA, NGS ;

REZKALLAHIWASSO, MT ;

PERACOLI, MTS ;

AUDI, RC ;

MENDES, RP ;

MARCONDES, J ;

MARQUES, SA ;

DILLON, NL ;

FRANCO, MF .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1985, 79 (06) :765-772

← 1 2 →