A trypanosome structure involved in transmitting cytoplasmic information during cell division

被引：121

作者：

Moreira-Leite, FF ^{[1
]}

Sherwin, T ^{[1
]}

Kohl, L ^{[1
]}

Gull, K ^{[1
]}

机构：

[1] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England

来源：

SCIENCE | 2001年 / 294卷 / 5542期

关键词：

D O I：

10.1126/science.1063775

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

African trypanosomes are protozoan parasites that cause sleeping sickness in humans through a tsetse fly vector. The procyclic form of Trypanosoma brucei has a single, attached flagellum that describes a helical path along the cell from posterior to anterior. During division, a specific flagellum-flagellum connection is elaborated between the new and old flagellum. This connector was present only during cell duplication and was found to be involved in the replication of the helical cell pattern and polarity. This finding implicates the concept of cytotaxis in cell morphogenesis in trypanosomes.

引用

页码：610 / 612

页数：3

共 20 条

[1]

Bastin P, 2000, J CELL SCI, V113, P3321

[2]

BASTIN P, 1996, PARASITOL TODAY, V12, P295

[3] CYTOPLASMIC INHERITANCE OF ORGANIZATION OF CELL CORTEX IN PARAMECIUM AURELIA [J].

BEISSON, J ;

SONNEBOR.TM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1965, 53 (02) :275-&

[4] Multigenerational cortical inheritance of the Rax2 protein in orienting polarity and division in yeast [J].

Chen, T ;

Hiroko, T ;

Chaudhuri, A ;

Inose, F ;

Lord, M ;

Tanaka, S ;

Chant, J ;

Fujita, A .

SCIENCE, 2000, 290 (5498) :1975-1978

[5] DELETION OF AN IMMUNODOMINANT TRYPANOSOMA-CRUZI SURFACE GLYCOPROTEIN DISRUPTS FLAGELLUM CELL-ADHESION [J].

COOPER, R ;

DEJESUS, AR ;

CROSS, GAM .

JOURNAL OF CELL BIOLOGY, 1993, 122 (01) :149-156

[6]

DOLAN MT, 1986, J CELL SCI, V80, P123

[7] Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans [J].

Fire, A ;

Xu, SQ ;

Montgomery, MK ;

Kostas, SA ;

Driver, SE ;

Mello, CC .

NATURE, 1998, 391 (6669) :806-811

[8]

GRIMES GW, 1982, AM ZOOL, V22, P35

[9] The cytoskeleton of trypanosomatid parasites [J].

Gull, K .

ANNUAL REVIEW OF MICROBIOLOGY, 1999, 53 :629-+

[10] Assembly of the paraflagellar rod and the flagellum attachment zone complex during the Trypanosoma brucei cell cycle [J].

Kohl, L ;

Sherwin, T ;

Gull, K .

JOURNAL OF EUKARYOTIC MICROBIOLOGY, 1999, 46 (02) :105-109

← 1 2 →