Convergence of the secretory pathways for cholera toxin and the filamentous phage, CTXφ

被引：87

作者：

Davis, BM

Lawson, EH

Sandkvist, M

Ali, A

Sozhamannan, S

Waldor, MK ^{[1
]}

机构：

[1] Tufts Univ, Sch Med, Div Geog Med & Infect Dis, Boston, MA 02111 USA

[2] Amer Red Cross, Holland Lab, Dept Biochem, Rockville, MD 20855 USA

[3] Univ Maryland, Sch Med, Dept Med, Div Hosp Epidemiol, Baltimore, MD 21201 USA

来源：

SCIENCE | 2000年 / 288卷 / 5464期

关键词：

D O I：

10.1126/science.288.5464.333

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Virulence of Vibrio cholerae depends on secretion of cholera toxin (CT), which is encoded within the genome of a filamentous phage, CTX phi. Release of CT is mediated by the extracellular protein secretion (eps) type II secretion system. Here. the outer membrane component of this system, EpsD, was shown to be required for secretion of the phage as well. Thus, EpsD plays a role both in pathogenicity and in horizontal transfer of a key virulence gene. Genomic analysis suggests that additional filamentous phages also exploit chromosome-encoded outer membrane channels.

引用

页码：333 / 335

页数：3

共 22 条

[1] Mutations in the extracellular protein secretion pathway genes (eps) interfere with rugose polysaccharide production in and motility of Vibrio cholerae [J].