Agrin in the developing CNS:: New roles for a synapse organizer

被引:43
作者
Kröger, S [1 ]
Schröder, JE [1 ]
机构
[1] Univ Mainz, Inst Physiol Chem & Pathobiochem, D-55099 Mainz, Germany
来源
NEWS IN PHYSIOLOGICAL SCIENCES | 2002年 / 17卷
关键词
D O I
10.1152/01390.2002
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The heparan sulfate proteoglycan agrin is responsible for the formation, maintenance, and regeneration of the neuromuscular junction. In the central nervous system, agrin is widely expressed and concentrated at interneuronal synapses, but its function during synaptogenesis remains controversial. Instead, evidence for additional functions of agrin during axonal growth, establishment of the blood-brain barrier, and Alzheimer's disease is accumulating.
引用
收藏
页码:207 / 212
页数:6
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