Synthesis and biological evaluation of 1,3,4-triaryl-3-pyrrolin-2-ones, a new class of selective cyclooxygenase-2 inhibitors

被引：34

作者：

Bosch, J ^{[1
]}

Roca, T

Catena, JL

Llorens, O

Pérez, JJ

Lagunas, C

Fernández, AG

Miquel, I

Fernández-Serrat, A

Farrerons, C

机构：

[1] Univ Barcelona, Fac Pharm, Organ Chem Lab, E-08028 Barcelona, Spain

[2] Tech Univ Catalonia, Dept Chem Engn, Barcelona 08028, Spain

[3] Labs SALVAT SA, R&D Ctr, Barcelona 08950, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(00)00329-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and structure-activity relationships (SAR) of a series of novel selective COX-2 inhibitors are reported. The results show that some of the 1,3,4-triaryl-3-pyrrolin-2-ones 1 are more potent as COX-2 inhibitors than celecoxib, and that lactam 1d has the same selectivity. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1745 / 1748

页数：4

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