Alzheimer's disease amyloid beta converting left-handed Z-DNA back to right-handed B-form

被引：45

作者：

Geng, Jie ^{[1
]}

Zhao, Chuanqi ^{[1
]}

Ren, Jinsong ^{[1
]}

Qu, Xiaogang ^{[1
]}

机构：

[1] Chinese Acad Sci, Biol Chem Lab, Div Biol Inorgan Chem,Grad Sch, Changchun Inst Appl Chem,State Key Lab Rare Earth, Changchun 130022, Jilin, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 38期

关键词：

ENDOPLASMIC-RETICULUM; PEPTIDE AGGREGATION; SYNTHETIC DNA; FIBRILS; PROTEIN; TRANSITIONS; POLY(DG-DC); OLIGOMERS; CURCUMIN; SEQUENCE;

D O I：

10.1039/c0cc02049d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein we report that A beta aggregates, not A beta monomer, can convert Z-DNA back to B-form, and curcumin, a well-known A beta aggregation inhibitor, can stop DNA Z-B transition studied by means of biophysical and biochemical methods.

引用

页码：7187 / 7189

页数：3

共 39 条

[1] Detection of β-amyloid peptide aggregation using DNA electrophoresis [J].

Ahn, BW ;

Song, DU ;

Jung, YD ;

Chay, KO ;

Chung, MA ;

Yang, SY ;

Shin, BA .

ANALYTICAL BIOCHEMISTRY, 2000, 284 (02) :401-405

[2]

BRESLOW JL, 1982, J BIOL CHEM, V257, P4639

[3] Cytosolic and nuclear aggregation of the amyloid β-peptide following its expression in the endoplasmic reticulum [J].

Bückig, A ;

Tikkanen, R ;

Herzog, V ;

Schmitz, A .

HISTOCHEMISTRY AND CELL BIOLOGY, 2002, 118 (05) :353-360

[4] Nature and significance of the interactions between amyloid fibrils and biological polyelectrolytes [J].

Calamai, Martino ;

Kumita, Janet R. ;

Mifsud, John ;

Parrini, Claudia ;

Ramazzotti, Matteo ;

Ramponi, Giampietro ;

Taddei, Niccolo ;

Chiti, Fabrizio ;

Dobson, Christopher M. .

BIOCHEMISTRY, 2006, 45 (42) :12806-12815

[5] The epigenetic effects of amyloid-β1-40 on global DNA and neprilysin genes in murine cerebral endothelial cells [J].

Chen, Un-Lin ;

Wang, Steven Sheng-Shih ;

Yang, Yi-Yuan ;

Yuan, Rey-Yue ;

Chen, Ruei-Ming ;

Hu, Chaur-Jong .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 378 (01) :57-61

[6] SECONDARY STRUCTURAL COMPLEMENTARITY BETWEEN DNA AND PROTEINS [J].

CHURCH, GM ;

SUSSMAN, JL ;

KIM, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (04) :1458-1462

[7] DNA converts cellular prion protein into the β-sheet conformation and inhibits prion peptide aggregation [J].

Cordeiro, Y ;

Machado, F ;

Juliano, L ;

Juliano, MA ;

Brentani, RR ;

Foguel, D ;

Silva, JL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (52) :49400-49409

[8] Oligomeric and fibrillar species of amyloid-β peptides differentially affect neuronal viability [J].

Dahlgren, KN ;

Manelli, AM ;

Stine, WB ;

Baker, LK ;

Krafft, GA ;

LaDu, MJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (35) :32046-32053

[9] EFFECT OF Z-DNA ON NUCLEOSOME PLACEMENT [J].

GARNER, MM ;

FELSENFELD, G .

JOURNAL OF MOLECULAR BIOLOGY, 1987, 196 (03) :581-590

[10]

Ginsberg SD, 1999, ANN NEUROL, V45, P174, DOI 10.1002/1531-8249(199902)45:2<174::AID-ANA7>3.0.CO

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