Up-regulation of vascular endothelial growth factor induced by hepatocyte growth factor scatter factor stimulation in human glioma cells

被引：65

作者：

Moriyama, T

Kataoka, H

Hamasuna, R

Yokogami, K

Uehara, H

Kawano, H

Goya, T

Tsubouchi, H

Koono, M

Wakisaka, S

机构：

[1] Miyazaki Med Coll, Dept Neurosurg, Miyazaki 88916, Japan

[2] Miyazaki Med Coll, Dept Pathol 2, Miyazaki 88916, Japan

[3] Miyazaki Med Coll, Dept Internal Med 2, Miyazaki 88916, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 249卷 / 01期

关键词：

D O I：

10.1006/bbrc.1998.9078

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent findings suggest that hepatocyte growth factor/scatter factor (HGF/SF) contributes to the malignant progression of human gliomas. We investigated the effect of HGF/SF on vascular endothelial growth factor (VEGF) expression of c-Met/HGF receptor-positive human glioma cell lines. Treatment of the glioma cells with various concentrations of HGF/SF resulted in an enhanced secretion of VEGF proteins accompanying increased transcription of VEGF mRNA in a dose-dependent fashion. Since malignant gliomas frequently co-express HGF/SF and its receptor, these results suggest that HGF/SF could act as an indirect angiogenic factor through autocrine induction of VEGF expression and secretion in malignant gliomas. (C) 1998 Academic Press.

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收藏

页码：73 / 77

页数：5

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