Integrated endoplasmic reticulum stress responses in cancer

被引：330

作者：

Moenner, Michel

Pluquet, Olivier

Bouchecareilh, Marion

Chevet, Eric ^{[1
]}

机构：

[1] Inst Natl Sante & Rech Med, Team Avenir, U889, F-33076 Bordeaux, France

[2] Inst Natl Sante & Rech Med, E0113, Talence, France

[3] Univ Bordeaux 1, F-33405 Talence, France

[4] Univ Bordeaux 2, F-33076 Bordeaux, France

来源：

CANCER RESEARCH | 2007年 / 67卷 / 22期

关键词：

D O I：

10.1158/0008-5472.CAN-07-1705

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The endoplasmic reticulurn (ER) has emerged as a major site of cellular homeostasis regulation, particularly in the unfolded protein response, which is being found to play a major role in cancer and many other diseases. Here, we address ER-mediated signaling and regulations in the context of environmental challenges in cancer, such as hypoxia, angiogenesis, and chemotherapeutic resistance, and we discuss how Ell-resident - molecular machines become deregulated and involved in cancer-related pathology. Further exploration of how the ER senses, signals, and adapts to stress may redefine and deepen our understanding of its functions in cancer pathobiology.

引用

收藏

页码：10631 / 10634

页数：4

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