Mesenchymal Stem Cell-Derived Exosomes: Immunomodulatory Evaluation in an Antigen-Induced Synovitis Porcine Model

被引：74

作者：

Casado, Javier G. ^{[1
,2
,3
]}

Blazquez, Rebeca ^{[1
,3
]}

Javier Vela, Francisco ^{[1
]}

Alvarez, Veronica ^{[1
]}

Tarazona, Raquel ^{[2
]}

Miguel Sanchez-Margallo, Francisco ^{[1
,3
]}

机构：

[1] Jesus Uson Minimally Invas Surg Ctr, Stem Cell Therapy Unit, Caceres, Spain

[2] Univ Extremadura, Dept Physiol, Immunol Unit, Caceres, Spain

[3] CIBER Enfermedades Cardiovasc, Caceres, Spain

来源：

FRONTIERS IN VETERINARY SCIENCE | 2017年 / 4卷

关键词：

exosomes; mesenchymal stem cells; synovitis; immunomodulation; inflammation; AUTOLOGOUS CONDITIONED SERUM; RHEUMATOID-ARTHRITIS; EXTRACELLULAR VESICLES; INTRAARTICULAR INJECTION; TRANSIENT SYNOVITIS; FLUID; OSTEOARTHRITIS; ANGIOGENESIS; IMPROVE; IL-8;

D O I：

10.3389/fvets.2017.00039

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

090604 [动物药学];

摘要：

Synovitis is an inflammatory process associated with pain, disability, and discomfort, which is usually treated with anti-inflammatory drugs or biological agents. Mesenchymal stem cells (MSCs) have been also successfully used in the treatment of inflammatory-related diseases such as synovitis or arthritis. In the last years, the exosomes derived from MSCs have become a promising tool for the treatment of inflammatory-related diseases and their therapeutic effect is thought to be mediated (at least in part) by their immunomodulatory potential. In this work, we aimed to evaluate the anti-inflammatory effect of these exosomes in an antigen-induced synovitis animal model. To our knowledge, this is the first report where exosomes derived from MSCs have been evaluated in an animal model of synovitis. Our results demonstrated a decrease of synovial lymphocytes together with a downregulation of TNF-alpha transcripts in those exosome-treated joints. These results support the immunomodulatory effect of these exosomes and point out that they may represent a promising therapeutic option for the treatment of synovitis.

引用

页数：10

共 73 条

[1]

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