Deflating the Genomic Bubble

被引:131
作者
Evans, James P. [1 ,2 ]
Meslin, Eric M. [3 ]
Marteau, Theresa M. [4 ]
Caulfield, Timothy [5 ,6 ]
机构
[1] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Dept Med, Chapel Hill, NC 27599 USA
[3] Indiana Univ, Ctr Bioeth, Indianapolis, IN 46202 USA
[4] Kings Coll London, Hlth Psychol Sect, London SE1 9RT, England
[5] Univ Alberta, Fac Law, Edmonton, AB T6G 2H5, Canada
[6] Univ Alberta, Hlth Law Inst, Sch Publ Hlth, Edmonton, AB T6G 2H5, Canada
基金
英国医学研究理事会;
关键词
RISK; ASSOCIATION; PERFORMANCE; VARIANTS;
D O I
10.1126/science.1198039
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Unrealistic expectations and uncritical translation of genetic discoveries may undermine other promising approaches to preventing disease and improving health.
引用
收藏
页码:861 / 862
页数:2
相关论文
共 34 条
[1]   The human genome at ten [J].
不详 .
NATURE, 2010, 464 (7289) :649-650
[2]  
[Anonymous], 2009, Gene transfer and the ethics of first-in-human research
[3]   10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study [J].
Bray, G. A. ;
Chatellier, A. ;
Duncan, C. ;
Greenway, F. L. ;
Levy, E. ;
Ryan, D. H. ;
Polonsky, K. S. ;
Tobian, J. ;
Ehrmann, D. ;
Matulik, M. J. ;
Clark, B. ;
Czech, K. ;
DeSandre, C. ;
Hilbrich, R. ;
McNabb, W. ;
Semenske, A. R. ;
Goldstein, B. J. ;
Smith, K. A. ;
Wildman, W. ;
Pepe, C. ;
Goldberg, R. B. ;
Calles, J. ;
Ojito, J. ;
Castillo-Florez, S. ;
Florez, H. J. ;
Giannella, A. ;
Lara, O. ;
Veciana, B. ;
Haffner, S. M. ;
Montez, M. G. ;
Lorenzo, C. ;
Martinez, A. ;
Hamman, R. F. ;
Testaverde, L. ;
Bouffard, A. ;
Dabelea, D. ;
Jenkins, T. ;
Lenz, D. ;
Perreault, L. ;
Price, D. W. ;
Steinke, S. C. ;
Horton, E. S. ;
Poirier, C. S. ;
Swift, K. ;
Caballero, E. ;
Jackson, S. D. ;
Lambert, L. ;
Lawton, K. E. ;
Ledbury, S. ;
Kahn, S. E. .
LANCET, 2009, 374 (9702) :1677-1686
[4]   Knowledge creation, entrepreneurship, and economic growth: a historical review [J].
Carlsson, Bo ;
Acs, Zoltan J. ;
Audretsch, David B. ;
Braunerhjelm, Pontus .
INDUSTRIAL AND CORPORATE CHANGE, 2009, 18 (06) :1193-1229
[5]   The commercialisation of medical and scientific reporting [J].
Caulfield, T .
PLOS MEDICINE, 2004, 1 (03) :178-179
[6]   Has the revolution arrived? [J].
Collins, Francis .
NATURE, 2010, 464 (7289) :674-675
[7]   Shattuck lecture - Medical and societal consequences of the human genome project [J].
Collins, FS .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (01) :28-37
[8]   Mortality in relation to smoking: 50 years' observations on male British doctors [J].
Doll, R ;
Peto, R ;
Boreham, J ;
Sutherland, I .
BMJ-BRITISH MEDICAL JOURNAL, 2004, 328 (7455) :1519-1528
[9]   A review of public policy issues in promoting the development and commercialization of pharmacogenomic applications: Challenges and implications [J].
Garrison, Louis P., Jr. ;
Carlson, Rick J. ;
Carlson, Josh J. ;
Kuszler, Patricia C. ;
Meckley, Lisa M. ;
Veenstra, David L. .
DRUG METABOLISM REVIEWS, 2008, 40 (02) :377-401
[10]   The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen [J].
Goetz, Matthew P. ;
Knox, Stacey K. ;
Suman, Vera J. ;
Rae, James M. ;
Safgren, Stephanie L. ;
Ames, Matthew M. ;
Visscher, Daniel W. ;
Reynolds, Carol ;
Couch, Fergus J. ;
Lingle, Wilma L. ;
Weinshilboum, Richard M. ;
Fritcher, Emily G. Barr ;
Nibbe, Andrea M. ;
Desta, Zeruesenay ;
Nguyen, Anne ;
Flockhart, David A. ;
Perez, Edith A. ;
Ingle, James N. .
BREAST CANCER RESEARCH AND TREATMENT, 2007, 101 (01) :113-121