Betulinic acid inhibits aminopeptidase N activity

被引：81

作者：

Melzig, MF ^{[1
]}

Bormann, H ^{[1
]}

机构：

[1] Humboldt Univ, Inst Pharm, D-13086 Berlin, Germany

来源：

PLANTA MEDICA | 1998年 / 64卷 / 07期

关键词：

D O I：

10.1055/s-2006-957542

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The triterpene betulinic acid inhibits the activity of aminopeptidase N (EC 3.4.11.2) in a dose-dependent manner. An IC50 of 7.3 +/- 1.4 mu M was determined for betulinic acid. This inhibitory activity is higher than that of bestatin (IC50 = 16.9 +/- 4.1 mu M), a well known inhibitor of this enzyme. The finding supports the idea that betulinic acid acts as anti-melanoma agent via inhibition of aminopeptidase N activity.

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页码：655 / 657

页数：3

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