The VHL tumour-suppressor gene paradigm

被引：194

作者：

Kaelin, WG ^{[1
]}

Maher, ER

机构：

[1] Dana Farber Canc Hosp, Div Adult Oncol, Boston, MA 02116 USA

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02116 USA

[3] Univ Birmingham, Dept Paediat & Child Hlth, Div Med & Mol Genet, Birmingham B15 2TT, W Midlands, England

来源：

TRENDS IN GENETICS | 1998年 / 14卷 / 10期

关键词：

D O I：

10.1016/S0168-9525(98)01558-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The VHL, tumour-suppressor gene (TSG) has a critical 'gatekeeper' role in regulating growth and differentiation of human kidney cells, and inactivation of the VHL gene is the most frequent genetic event in human kidney cancer. There are many similarities between tbe genetics of the VHL asd retinoblastoma TSGs, but the VHL tumourigenesis model is more complex, Here, we examine tbe current knowledge of the genetics and functional aspects of tbe VHL TSG, and emphasize How the VHL gene provides a paradigm that Illustrates many aspects of TSG biology.

引用

页码：423 / 426

页数：4

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