The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

被引：3662

作者：

Gibson, Glenn R. ^{[1
]}

Hutkins, Robert ^{[2
]}

Sanders, Mary Ellen ^{[3
]}

Prescott, Susan L. ^{[4
]}

Reimer, Raylene A. ^{[5
,6
]}

Salminen, Seppo J. ^{[7
]}

Scott, Karen ^{[8
]}

Stanton, Catherine ^{[9
]}

Swanson, Kelly S. ^{[10
]}

Cani, Patrice D. ^{[11
]}

Verbeke, Kristin ^{[12
,13
]}

Reid, Gregor ^{[14
]}

机构：

[1] Univ Reading, Dept Food & Nutr Sci, POB 226, Reading RG6 6AP, Berks, England

[2] Univ Nebraska, Food Innovat Ctr 258, Dept Food Sci & Technol, Lincoln, NE 68588 USA

[3] Int Sci Assoc Probiot & Prebiot, 7119 S Glencoe Court, Centennial, CO 80122 USA

[4] Univ Western Australia, Sch Paediat & Child Hlth, 35 Stirling Highway, Perth, WA 6009, Australia

[5] Univ Calgary, Cumming Sch Med, Fac Kinesiol, 2500 Univ Dr, Calgary, AB, Canada

[6] Univ Calgary, Cumming Sch Med, Dept Biochem & Mol Biol, 2500 Univ Dr, Calgary, AB, Canada

[7] Univ Turku, Funct Foods Forum, Fac Med, Itainen Pitkakatu 4A, FI-20014 Turku, Finland

[8] Univ Aberdeen, Rowett Inst Nutr & Hlth, Aberdeen AB21 9SB, Scotland

[9] Teagasc Moorepk Food Res Ctr, Fermoy P61 C996, Cork, Ireland

[10] Univ Illinois, Dept Anim Sci, 1207 W Gregory Dr, Urbana, IL 61801 USA

[11] Catholic Univ Louvain, Louvain Drug Res Inst, WELBIO Walloon Excellence Life Sci & Biotechnol, Metab & Nutr Res Grp, 73 Ave Mounier, B-1200 Brussels, Belgium

[12] Katholieke Univ Leuven, Translat Res Gastrointestinal Disorders, Targid Herestr 49, Leuven, Belgium

[13] Leuven Food Sci & Nutr Res Ctr, Targid Herestr 49, Leuven, Belgium

[14] Univ Western Ontario, Lawson Hlth Res Inst, 268 Grosvenor St, London, ON N6A 4V2, Canada

来源：

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2017年 / 14卷 / 08期

关键词：

CHAIN FATTY-ACIDS; GALACTO-OLIGOSACCHARIDE MIXTURE; HUMAN-MILK OLIGOSACCHARIDES; HUMAN COLONIC MICROBIOTA; GLUCAGON-LIKE PEPTIDE-1; GUT MICROBIOTA; ESCHERICHIA-COLI; GROWTH-PERFORMANCE; DIETARY FIBER; INSULIN SENSITIVITY;

D O I：

10.1038/nrgastro.2017.75

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

In December 2016, a panel of experts in microbiology, nutrition and clinical research was convened by the International Scientific Association for Probiotics and Prebiotics to review the definition and scope of prebiotics. Consistent with the original embodiment of prebiotics, but aware of the latest scientific and clinical developments, the panel updated the definition of a prebiotic: a substrate that is selectively utilized by host microorganisms conferring a health benefit. This definition expands the concept of prebiotics to possibly include non-carbohydrate substances, applications to body sites other than the gastrointestinal tract, and diverse categories other than food. The requirement for selective microbiota-mediated mechanisms was retained. Beneficial health effects must be documented for a substance to be considered a prebiotic. The consensus definition applies also to prebiotics for use by animals, in which microbiota-focused strategies to maintain health and prevent disease is as relevant as for humans. Ultimately, the goal of this Consensus Statement is to engender appropriate use of the term 'prebiotic' by relevant stakeholders so that consistency and clarity can be achieved in research reports, product marketing and regulatory oversight of the category. To this end, we have reviewed several aspects of prebiotic science including its development, health benefits and legislation.

引用

页码：491 / 502

页数：12

共 154 条

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