Magnesium and MK-801 have a similar effect in two experimental models of neuropathic pain

被引：69

作者：

Begon, S ^{[1
]}

Pickering, G ^{[1
]}

Eschalier, A ^{[1
]}

Dubray, C ^{[1
]}

机构：

[1] INSERM, EPI 9904, Lab Pharmacol Med, Fac Med, F-63001 Clermont Ferrand 1, France

来源：

BRAIN RESEARCH | 2000年 / 887卷 / 02期

关键词：

neuropathic pain; hyperalgesia; magnesium; MK-801;

D O I：

10.1016/S0006-8993(00)03028-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Considering that magnesium and non-competitive NMDA receptor antagonists inhibit the opening of the channel linked to the NMDA receptor. we assessed their effects on mechanical hyperalgesia in two animal models of neuropathic pain (rats with a sciatic nerve ligature and diabetic rats). Our data show that magnesium reverses the hyperalgesia, as does MK-801. These results suggest that magnesium could be an alternative for the treatment of neuropathic pain in patients. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：436 / 439

页数：4

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