ERG changes in albino and pigmented mice after optic nerve transection

被引：55

作者：

Alarcon-Martinez, Luis ^{[1
]}

Aviles-Trigueros, Marcelino ^{[1
]}

Galindo-Romero, Caridad ^{[1
]}

Valiente-Soriano, Javier ^{[1
]}

Agudo-Barriuso, Marta ^{[3
]}

de la Villa, Pedro ^{[2
]}

Villegas-Perez, Maria P. ^{[1
]}

Vidal-Sanz, Manuel ^{[1
]}

机构：

[1] Univ Murcia, Dept Oftalmol, Fac Med, E-30100 Murcia, Spain

[2] Univ Alcala de Henares, Dept Fisiol, Alcala De Henares 28871, Spain

[3] Fdn Formac & Invest Sanitarias Reg Murcia, Unidad Invest, Hosp Univ Virgen Arrixaca, Serv Murciano Salud, Murcia 30120, Spain

来源：

VISION RESEARCH | 2010年 / 50卷 / 21期

关键词：

Electroretinogram (ERG); Scotopic threshold response (STR); Optic nerve transection (ONT); Axotomy; Retinal ganglion cells (RGCs); Adult albino and pigmented mice; Neuronal degeneration; Retina; RETINAL GANGLION-CELLS; SCOTOPIC THRESHOLD RESPONSE; PHOTOPIC NEGATIVE RESPONSE; DARK-ADAPTED ELECTRORETINOGRAM; INDUCED OCULAR HYPERTENSION; SUPERIOR COLLICULUS; FUNCTIONAL-CHANGES; MICROGLIAL CELLS; TROPHIC FACTORS; UP-REGULATION;

D O I：

10.1016/j.visres.2010.08.014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Optic nerve transection (ONT) triggers retinal ganglion cell (RGC) death. By using this paradigm, we have analyzed for the first time in adult albino and pigmented mice, the effects of ONT in the scotopic threshold response (STR) components (negative and positive) of the full-field electroretinogram. Two weeks after ONT, when in pigmented mice approximately 18% of the RGC population survive, the STR-implicit time decreased and the p and nSTR waves diminished approximately to 40% or 55%, in albino or pigmented, respectively, with respect to the values recorded from the non-operated contralateral eyes. These changes were maintained up to 12 weeks post-ONT, demonstrating that the ERG-SIR is a useful parameter to monitor RGC functionality in adult mice. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2176 / 2187

页数：12

共 86 条

[1]

GROWTH AND CONNECTIVITY OF AXOTOMIZED RETINAL NEURONS IN ADULT-RATS WITH OPTIC NERVES SUBSTITUTED BY PNS GRAFTS LINKING THE EYE AND THE MIDBRAIN [J].