Regulatory locus soxRS partially protects Escherichia coli against ozone

被引：8

作者：

Jiménez-Arribas, G ^{[1
]}

Léautaud, V ^{[1
]}

Amabile-Cuevas, CF ^{[1
]}

机构：

[1] Fdn LUSARA, Mexico City 08930, DF, Mexico

来源：

FEMS MICROBIOLOGY LETTERS | 2001年 / 195卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Escherichia coli; ozone; soxRS locus;

D O I：

10.1016/S0378-1097(01)00007-6

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ozone is one of the major city air pollutants. Since it is known to induce the overexpression of superoxide-dismutase in various models, and is also a powerful oxidant, we tested if ozone can induce the expression of the soxRS regulon of Escherichia coli, which is activated by superoxide and nitric oxide. A sub-lethal exposure to ozone was unable to activate the expression of soxS' :: lacZ transcriptional fusions. However, cells lacking the soxRS locus were more susceptible than wild-type to ozone-mediated killing. Constitutive expression of the soxRS did not increase the resistance to ozone. Ozone might be exerting a selective pressure upon oxidative-stress defense mechanisms in airborne bacteria. (C) 2001 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：175 / 177

页数：3

共 21 条

[1] MOLECULAR CHARACTERIZATION OF THE SOXRS GENES OF ESCHERICHIA-COLI - 2 GENES CONTROL A SUPEROXIDE STRESS REGULON [J].