Chiral separation of pharmaceuticals possessing a carboxy moiety

被引：30

作者：

Arai, T ^{[1
]}

机构：

[1] Daiichi Pharmaceut Co Ltd, Med Dev Dept, Edogawa Ku, Tokyo 1348630, Japan

来源：

JOURNAL OF CHROMATOGRAPHY B | 1998年 / 717卷 / 1-2期

关键词：

reviews; enantiomer separation; carboxylic acids;

D O I：

10.1016/S0378-4347(98)00246-1

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The separation of carboxylic enantiomers in the pharmaceutical field using high-performance liquid chromatographic and capillary electrophoretic techniques is reviewed. The techniques used for chiral separation include diastereomer derivatization, a chiral mobile phase, a chiral stationary phase (high-performance liquid chromatography) and chiral additives (capillary electrophoresis), Practical and conventional separation systems for pharmaceutical applications, such as pharmacokinetics, optical purity testing and stability studies, are described. A comprehensive collection of applications to carboxylic drugs and other carboxylic compounds of pharmaceutical interest is listed in the tables. The characteristics of each enantioseparation method are also discussed briefly. (C) 1998 Published by Elsevier Science B.V. All rights reserved.

引用

页码：295 / 311

页数：17

共 105 条

[1] SOME MECHANISTIC ASPECTS ON CHIRAL DISCRIMINATION OF ORGANIC-ACIDS BY IMMOBILIZED BOVINE SERUM-ALBUMIN (BSA) [J].

ALLENMARK, S ;

ANDERSSON, S .

CHIRALITY, 1992, 4 (01) :24-29

[2]

ARAI T, 1989, BUNSEKI KAGAKU, V38, P650

[3] CHIRAL SEPARATION BY CAPILLARY AFFINITY ZONE ELECTROPHORESIS USING AN ALBUMIN-CONTAINING SUPPORT ELECTROLYTE [J].

ARAI, T ;

ICHINOSE, M ;

KURODA, H ;

NIMURA, N ;

KINOSHITA, T .

ANALYTICAL BIOCHEMISTRY, 1994, 217 (01) :7-11

[4] INVESTIGATION OF ENANTIOSELECTIVE OFLOXACIN-ALBUMIN BINDING AND DISPLACEMENT INTERACTIONS USING CAPILLARY AFFINITY ZONE ELECTROPHORESIS [J].

ARAI, T ;

NIMURA, N ;

KINOSHITA, T .

BIOMEDICAL CHROMATOGRAPHY, 1995, 9 (02) :68-74

[5]

Arai T, 1996, J CHROMATOGR A, V736, P303

[6] DETERMINATION OF OPTICAL PURITY BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ON CHIRAL STATIONARY PHASES - PANTOTHENIC-ACID AND RELATED-COMPOUNDS [J].

ARAI, T ;

MATSUDA, H ;

OIZUMI, H .

JOURNAL OF CHROMATOGRAPHY, 1989, 474 (02) :405-410

[7] SEPARATION OF PYRIDONE CARBOXYLIC-ACID ENANTIOMERS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY USING COPPER(II)-L-AMINO ACID AS THE ELUENT [J].

ARAI, T ;

KOIKE, H ;

HIRATA, K ;

OIZUMI, H .

JOURNAL OF CHROMATOGRAPHY, 1988, 448 (03) :439-444

[8]

ARAI T, 1994, BUNSEKI KAGAKU, V43, P1201

[9] EVALUATION OF THE MACROCYCLIC ANTIBIOTIC VANCOMYCIN AS A CHIRAL SELECTOR FOR CAPILLARY ELECTROPHORESIS [J].

ARMSTRONG, DW ;

RUNDLETT, KL ;

CHEN, JR .

CHIRALITY, 1994, 6 (06) :496-509

[10] HIGHLY ENANTIOSELECTIVE CAPILLARY ELECTROPHORETIC SEPARATIONS WITH DILUTE-SOLUTIONS OF THE MACROCYCLIC ANTIBIOTIC RISTOCETIN-A [J].

ARMSTRONG, DW ;

GASPER, MP ;

RUNDLETT, KL .

JOURNAL OF CHROMATOGRAPHY A, 1995, 689 (02) :285-304

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