Primary open-angle glaucoma, intraocular pressure, and diabetes mellitus in the general elderly population - The Rotterdam study

被引:195
作者
Dielemans, I
deJong, PTVM
Stolk, R
Vingerling, JR
Grobbee, DE
Hofman, A
机构
[1] NETHERLANDS OPHTHALM RES INST,NL-1100 AC AMSTERDAM,NETHERLANDS
[2] ERASMUS UNIV ROTTERDAM,SCH MED,INST OPHTHALMOL,ROTTERDAM,NETHERLANDS
[3] ERASMUS UNIV ROTTERDAM,DEPT EPIDEMIOL & BIOSTAT,SCH MED,NL-3000 DR ROTTERDAM,NETHERLANDS
[4] UNIV AMSTERDAM,ACAD MED CTR,DEPT OPHTHALMOL,NL-1105 AZ AMSTERDAM,NETHERLANDS
关键词
D O I
10.1016/S0161-6420(96)30511-3
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: To investigate the association of primary open-angle glaucoma and intraocular pressure (IOP) with newly diagnosed diabetes mellitus. Methods: Subjects participating in the Rotterdam Study (n = 4178; ages, 55 years and older) were examined according to standard protocols, including a medical history interview, perimetry, applanation tonometry, funduscopy, and a nonfasting glucose tolerance test. Glaucoma was defined by the presence of a glaucomatous visual field defect. A distinction was made between high-tension glaucoma and normal-tension glaucoma. The relation of glaucoma and IOP with newly diagnosed diabetes mellitus and blood glucose was analyzed using regression analysis. Results: The presence of diabetes mellitus was associated with an overall rise in mean IOP of both eyes of 0.31 mmHg (95% confidence interval, 0.12-0.50), and with a threefold increased presence of high-tension glaucoma (odds ratio, 3.11; 95% confidence interval, 1.12-8.66). A 10-mmol/l higher random serum glucose level was borderline significantly associated with a mean IOP that was, on average, 0.41 mmHg (95% confidence interval, -0.02-0.84) higher and with an odds ratio of 2.82 (95% confidence interval, 0.92-8.58) for high-tension glaucoma. A 10-mmol/l rise in serum glucose on a glucose tolerance test was associated with an overall rise of mean IOP of 0.59 mmHg (95% confidence interval, 0.26-0.92) and with an odds ratio of 1.88 (95% confidence interval, 0.81-4.32) for high-tension glaucoma. Conclusion: Newly diagnosed diabetes mellitus and high levels of blood glucose are associated with elevated IOP and high-tension glaucoma.
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页码:1271 / 1275
页数:5
相关论文
共 18 条
[1]   DIABETES MELLITUS AND EYE .2. INTRAOCULAR PRESSURE AND AQUEOUS OUTFLOW FACILITY [J].
ARMALY, MF ;
BALOGLOU, PJ .
ARCHIVES OF OPHTHALMOLOGY, 1967, 77 (04) :493-&
[2]  
BECKER B, 1971, AM J OPHTHALMOL, V70, P1
[3]   INTRAOCULAR PRESSURE IN DIABETES - RELATIONSHIP TO RETINOPATHY AND BLOOD GLUCOSE LEVEL [J].
BOUZAS, AG ;
GRAGOUDAS, ES ;
BALODIMOS, MC ;
BRINEGAR, CH ;
AIELLO, LM .
ARCHIVES OF OPHTHALMOLOGY, 1971, 85 (04) :423-+
[4]  
CAREL RS, 1984, OPHTHALMOLOGY, V91, P311
[5]  
CHRISTIANSSON J, 1961, ACTA OPHTHALMOL, V39, P155
[6]  
DIELEMANS I, 1994, OPHTHALMOLOGY, V101, P1851
[7]   RELIABILITY OF INTRAOCULAR-PRESSURE MEASUREMENT WITH THE GOLDMANN APPLANATION TONOMETER IN EPIDEMIOLOGIC STUDIES [J].
DIELEMANS, I ;
VINGERLING, JR ;
HOFMAN, A ;
GROBBEE, DE ;
DEJONG, PTVM .
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 1994, 232 (03) :141-144
[8]   EPIDEMIOLOGICAL ASPECTS OF OCULAR HYPERTENSION [J].
GANLEY, JP .
SURVEY OF OPHTHALMOLOGY, 1980, 25 (03) :130-135
[9]   DETERMINANTS OF DISEASE AND DISABILITY IN THE ELDERLY - THE ROTTERDAM ELDERLY STUDY [J].
HOFMAN, A ;
GROBBEE, DE ;
DEJONG, PTVM ;
VANDENOUWELAND, FA .
EUROPEAN JOURNAL OF EPIDEMIOLOGY, 1991, 7 (04) :403-422
[10]   DIABETIC RETINOPATHY - ITS RELATIONSHIP WITH INTRAOCULAR PRESSURE [J].
JAIN, IS ;
LUTHRA, CL .
ARCHIVES OF OPHTHALMOLOGY, 1967, 78 (02) :198-&