Hepatitis E Virus Seroprevalence among Blood Donors in Southwest Switzerland

被引:79
作者
Kaufmann, Annatina [1 ]
Kenfak-Foguena, Alain [2 ]
Andre, Cyril [3 ]
Canellini, Giorgia [4 ]
Buergisser, Philippe [3 ]
Moradpour, Darius [5 ]
Darling, Katharine E. A. [2 ]
Cavassini, Matthias [2 ]
机构
[1] Univ Lausanne, Fac Biol & Med, Lausanne, Switzerland
[2] CHU Vaudois, Infect Dis Serv, Lausanne, Switzerland
[3] CHU Vaudois, Serv Immunol & Allergy, Lausanne, Switzerland
[4] Serv Reg Vaudois Transfus Sanguine, Epalinges, Switzerland
[5] CHU Vaudois, Div Gastroenterol & Hepatol, Lausanne, Switzerland
来源
PLOS ONE | 2011年 / 6卷 / 06期
关键词
IGG SEROPREVALENCE; UNITED-STATES; PREVALENCE; ANTIBODIES; ENGLAND; INFECTION;
D O I
10.1371/journal.pone.0021150
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Aim: The aim of this study was to determine the seroprevalence of Hepatitis E virus (HEV) among blood donors in southwest Switzerland. Background: HEV is recognized as a food-borne disease in industrialized countries, transmitted mainly through pork meat. Cases of transmission through blood transfusion have also been reported. Recent studies have revealed seroprevalence rates of 13.5%, 16.6% and 20.6% among blood donors in England, France and Denmark, respectively. Methods: We analyzed 550 consecutive blood donor samples collected in the region of Lausanne, canton of Vaud, Switzerland, for the presence of anti-HEV IgG, using the MP Diagnostics HEV ELISA kit. For each donor, we documented age, sex and alanine aminotransferase (ALT) value. Results: The study panel was composed of 332 men (60.4%) and 218 women (39.6%). Overall, anti-HEV IgG was found in 27 of 550 samples (4.9%). The seroprevalence was 5.4% (18/332) in men and 4.1% (9/218) in women. The presence of anti-HEV IgG was not correlated with age, gender or ALT values. However, we observed a peak in seroprevalence of 5.3% in individuals aged 51 to 70 years old. Conclusions: Compared with other European countries, HEV seroprevalence among blood donors in southwest Switzerland is low. The low seroprevalence may be explained by the sensitivity of commercial tests used and/or the strict regulation of animal and meat imports. Data regarding HEV prevalence in Swiss livestock are lacking and merit exploration.
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