Molecular pathogenesis of diffuse large B-cell lymphoma

被引：65

作者：

Schneider, Christof ^{[2
,3
]}

Pasqualucci, Laura ^{[2
,3
,4
]}

Dalla-Favera, Riccardo ^{[1
,2
,3
,4
]}

机构：

[1] Columbia Univ, Dept Genet & Dev, New York, NY 10032 USA

[2] Columbia Univ, Inst Canc Genet, New York, NY 10032 USA

[3] Columbia Univ, Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USA

[4] Columbia Univ, Dept Clin Pathol & Cell Biol, New York, NY 10032 USA

来源：

SEMINARS IN DIAGNOSTIC PATHOLOGY | 2011年 / 28卷 / 02期

关键词：

DLBCL; Genetic lesions; Germinal center; NF-KAPPA-B; NON-HODGKINS-LYMPHOMA; CLASS-SWITCH RECOMBINATION; DEREGULATED BCL6 EXPRESSION; CYTIDINE DEAMINASE AID; TUMOR-SUPPRESSOR GENE; FINGER ENCODING GENE; AFFECTING BAND 3Q27; GERMINAL-CENTER; CHROMOSOMAL TRANSLOCATIONS;

D O I：

10.1053/j.semdp.2011.04.001

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

In past years, substantial insight regarding the pathogenesis of diffuse large B-cell lymphoma has been obtained. Particularly, based on gene expression profile analysis, this disease can be classified into distinct phenotypic subgroups and specific transcriptional programs have been identified. New technologies like next-generation whole genome/exome sequencing and genome-wide single nucleotide polymorphism array analysis have revealed novel lesions involved in the pathogenesis of this disease. This review focuses on the diversity of genetic lesions identified in the different subtypes of diffuse large B-cell lymphoma. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：167 / 177

页数：11

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