Regional cortical thinning in preclinical Huntington disease and its relationship to cognition

被引：239

作者：

Rosas, HD

Hevelone, ND

Zaleta, AK

Greve, DN

Salat, DH

Fischl, B

机构：

[1] Harvard Univ, Sch Med, Ctr Neuroimaging Aging & Neurodegenerat Dis, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Charlestown, MA 02129 USA

[3] Harvard Univ, Sch Med, Dept Neurol, Boston, MA USA

[4] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Boston, MA USA

[5] Athinoula A Martinos Ctr Biomed Imainging, Charlestown, MA USA

来源：

NEUROLOGY | 2005年 / 65卷 / 05期

关键词：

D O I：

10.1212/01.wnl.0000174432.87383.87

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors studied presymptomatic individuals with the Huntington disease (HD) mutation to determine whether cortical thinning was present. They found thinning that was regionally selective, semi-independent of striatal volume loss, and correlated with cognitive performance. Early, extensive cortical involvement occurs during the preclinical stages of HD.

引用

页码：745 / 747

页数：3

共 9 条

[1] Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutation [J].

Behrens, P. F. ;

Franz, P. ;

Woodman, B. ;

Lindenberg, K. S. ;

Landwehrmeyer, G. B. .

BRAIN, 2002, 125 :1908-1922

[2] HUNTINGTIN IS A CYTOPLASMIC PROTEIN ASSOCIATED WITH VESICLES IN HUMAN AND RAT-BRAIN NEURONS [J].

DIFIGLIA, M ;

SAPP, E ;

CHASE, K ;

SCHWARZ, C ;

MELONI, A ;

YOUNG, C ;

MARTIN, E ;

VONSATTEL, JP ;

CARRAWAY, R ;

REEVES, SA ;

BOYCE, FM ;

ARONIN, N .

NEURON, 1995, 14 (05) :1075-1081

[3] Whole brain segmentation: Automated labeling of neuroanatomical structures in the human brain [J].

Fischl, B ;

Salat, DH ;

Busa, E ;

Albert, M ;

Dieterich, M ;

Haselgrove, C ;

van der Kouwe, A ;

Killiany, R ;

Kennedy, D ;

Klaveness, S ;

Montillo, A ;

Makris, N ;

Rosen, B ;

Dale, AM .

NEURON, 2002, 33 (03) :341-355

[4]

Gutekunst CA, 1999, J NEUROSCI, V19, P2522

[5] Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease [J].

Laforet, GA ;

Sapp, E ;

Chase, K ;

McIntyre, C ;

Boyce, FM ;

Campbell, M ;

Cadigan, BA ;

Warzecki, L ;

Tagle, DA ;

Reddy, PH ;

Cepeda, C ;

Calvert, CR ;

Jokel, ES ;

Klapstein, GJ ;

Ariano, MA ;

Levine, MS ;

DiFiglia, M ;

Aronin, N .

JOURNAL OF NEUROSCIENCE, 2001, 21 (23) :9112-9123

[6] Regional and progressive thinning of the cortical ribbon in Huntington's disease [J].

Rosas, HD ;

Liu, AK ;

Hersch, S ;

Glessner, M ;

Ferrante, RJ ;

Salat, DH ;

van der Kouwe, A ;

Jenkins, BG ;

Dale, AM ;

Fischl, B .

NEUROLOGY, 2002, 58 (05) :695-701

[7] WIDESPREAD EXPRESSION OF HUNTINGTONS-DISEASE GENE (IT15) PROTEIN PRODUCT [J].

SHARP, AH ;

LOEV, SJ ;

SCHILLING, G ;

LI, SH ;

LI, XJ ;

BAO, J ;

WAGSTER, MV ;

KOTZUK, JA ;

STEINER, JP ;

LO, A ;

HEDREEN, J ;

SISODIA, S ;

SNYDER, SH ;

DAWSON, TM ;

RYUGO, DK ;

ROSS, CA .

NEURON, 1995, 14 (05) :1065-1074

[8]

Vonsattel JPG, 1998, J NEUROPATH EXP NEUR, V57, P369

[9] Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease [J].

Zuccato, C ;

Ciammola, A ;

Rigamonti, D ;

Leavitt, BR ;

Goffredo, D ;

Conti, L ;

MacDonald, ME ;

Friedlander, RM ;

Silani, V ;

Hayden, MR ;

Timmusk, T ;

Sipione, S ;

Cattaneo, E .

SCIENCE, 2001, 293 (5529) :493-498

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