Easy access to bioactive peptide-polymer conjugates via RAFT

被引：100

作者：

Hentschel, Jens ^{[1
]}

Bleek, Katrin ^{[1
]}

Ernst, Oliver ^{[2
]}

Lutz, Jean-Francois ^{[3
]}

Boerner, Hans G. ^{[1
]}

机构：

[1] Max Planck Inst Colloids & Interfaces, MPI KGF, D-14424 Potsdam, Germany

[2] Fraunhofer IBMT, D-14476 Potsdam, Germany

[3] Fraunhofer IAP, D-14476 Potsdam, Germany

来源：

MACROMOLECULES | 2008年 / 41卷 / 04期

关键词：

D O I：

10.1021/ma8000934

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A fully automated one-step reaction approach to access bioactive peptide-chain-transfer agents (CTA) through reversible addition-fragmentation chain transfer radical polymerization (RAFT) was presented. The ratio of peptide/polymer measured by nuclear magnetic resonance (NMR) studies after deprotection of the peptide segment is found to match with the theoretical values. No cell rounding of spread fibroblasts occur on plain gold surfaces upon a temperature decrease from 37 to 25°C, such that the polymer-modified Au surface exhibits a switchability from dehydrated/cell attractant to a hydrated/cell repellant surface. The results show that well-defined oligopeptide-polymer conjugates can be accessed through a convenient and cost-effective RAFT polymerization route, utilizing a new type of R-group-anchored peptide-CTA.

引用

页码：1073 / 1075

页数：3

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