Evolving endosomes: how many varieties and why?

被引:104
作者
Perret, E [1 ]
Lakkaraju, A [1 ]
Deborde, S [1 ]
Schreiner, R [1 ]
Rodriguez-Boulan, E [1 ]
机构
[1] Cornell Univ, Weill Med Coll, Margaret Dyson Vis Res Inst, New York, NY 10021 USA
关键词
D O I
10.1016/j.ceb.2005.06.008
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The cell biologist's insight into endosomal diversity, in terms of both form and function, has increased dramatically in the past few years. This understanding has been promoted by the availability of powerful new techniques that allow imaging of both cargo and machinery in the endocytic process in real time, and by our ability to inhibit components of this machinery by RNA interference. The emerging picture from these studies is of a highly complex, dynamic and adaptable endosomal system that interacts at various points with the secretory system of the cell.
引用
收藏
页码:423 / 434
页数:12
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