N-myristoyltransferase:: a prospective drug target for protozoan parasites

被引：54

作者：

Bowyer, Paul W. ^{[1
,2
,3
]}

Tate, Edward W. ^{[2
]}

Leatherbarrow, Robin J. ^{[2
]}

Holder, Anthony A. ^{[4
]}

Smith, Deborah F. ^{[3
,5
]}

Brown, Katherine A. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Ctr Mol Microbiol & Infect, Div Cell & Mol Biol, London SW7 2AZ, England

[2] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

[3] Univ London Imperial Coll Sci Technol & Med, Wellcome Trust Labs Mol Parasitol, London SW7 2AZ, England

[4] Natl Inst Med Res Mill Hill, London Immunol & Infect Unit, Div Parasitol, London, England

[5] Univ York, Hull York Med Sch, Dept Biol, York YO10 5DD, N Yorkshire, England

来源：

CHEMMEDCHEM | 2008年 / 3卷 / 03期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

antiparasitic agents; drug development; lipids; peptidomimentics; structure-activity relationships;

D O I：

10.1002/cmdc.200700301

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(Chemical Equation Presented) Parasite specific: The inhibition of myristoyl-CoA:protein N-myristoyltransferase (NMT) can lead to parasite death in culture. Herein we review recent work that supports the suitability of NMT as a parasite-specific drug target. The example shown illustrates the peptidomimetic compound 2, which is more stable, yet retains the Ser and Lys functional groups of compound 1 that are necessary for NMT inhibition. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：402 / 408

页数：7

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