FOXA1: master of steroid receptor function in cancer

被引：168

作者：

Augello, Michael A. ^{[1
]}

Hickey, Theresa E. ^{[2
]}

Knudsen, Karen E. ^{[1
,3
,4
]}

机构：

[1] Thomas Jefferson Univ, Dept Canc Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

[2] Univ Adelaide, Sch Med, Dame Roma Mitchell Canc Res Lab, Hanson Inst, Adelaide, SA, Australia

[3] Thomas Jefferson Univ, Dept Urol, Philadelphia, PA 19107 USA

[4] Thomas Jefferson Univ, Dept Radiat Oncol, Philadelphia, PA 19107 USA

来源：

EMBO JOURNAL | 2011年 / 30卷 / 19期

关键词：

cancer; FOXA1; nuclear receptor; transcription factor; FORKHEAD BOX A1; HELIX TRANSCRIPTION FACTORS; NEGATIVE BREAST-CANCER; DNA-BINDING MOTIF; ANDROGEN RECEPTOR; PROSTATE-CANCER; DUCTAL MORPHOGENESIS; GLUCOSE-HOMEOSTASIS; LIVER DEVELOPMENT; BETA-CATENIN;

D O I：

10.1038/emboj.2011.340

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

FOXA transcription factors are potent, context-specific mediators of development that hold specialized functions in hormone-dependent tissues. Over the last several years, FOXA1 has emerged as a critical mediator of nuclear steroid receptor signalling, manifest at least in part through regulation of androgen receptor and oestrogen receptor activity. Recent findings point towards a major role for FOXA1 in modulating nuclear steroid receptor activity in breast and prostate cancer, and suggest that FOXA1 may significantly contribute to pro-tumourigenic phenotypes. The present review article will focus on the mechanisms, consequence, and clinical relevance of FOXA1-mediated steroid nuclear receptor signalling in human malignancy. The EMBO Journal (2011) 30, 3885-3894. doi:10.1038/emboj.2011.340; Published online 20 September 2011

引用

页码：3885 / 3894

页数：10

共 74 条

[1]

[Anonymous], BREAST CANC RES TREA

[2]

FOXA1 is an essential determinant of ERα expression and mammary ductal morphogenesis [J].

Bernardo, Gina M. ;

Lozada, Kristen L. ;

Miedler, John D. ;

Harburg, Gwyndolen ;

Hewitt, Sylvia C. ;

Mosley, Jonathan D. ;

Godwin, Andrew K. ;

Korach, Kenneth S. ;

Visvader, Jane E. ;

Kaestner, Klaus H. ;

Abdul-Karim, Fadi W. ;

Montano, Monica M. ;

Keri, Ruth A. .

DEVELOPMENT, 2010, 137 (12) :2045-2054

[3]

ANDROGENS INDUCE DIVERGENT PROLIFERATIVE RESPONSES IN HUMAN BREAST-CANCER CELL-LINES [J].

BIRRELL, SN ;

BENTEL, JM ;

HICKEY, TE ;

RICCIARDELLI, C ;

WEGER, MA ;

HORSFALL, DJ ;

TILLEY, WD .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1995, 52 (05) :459-467

[4]

A role for GATA-2 in transition to an aggressive phenotype in prostate cancer through modulation of key androgen-regulated genes [J].

Boehm, M. ;

Locke, W. J. ;

Sutherland, R. L. ;

Kench, J. G. ;

Henshall, S. M. .

ONCOGENE, 2009, 28 (43) :3847-3856

[5]

THE WINGED-HELIX DNA-BINDING MOTIF - ANOTHER HELIX-TURN-HELIX TAKEOFF [J].

BRENNAN, RG .

CELL, 1993, 74 (05) :773-776

[6]

Hormone Action in the Mammary Gland [J].

Brisken, Cathrin ;

O'Malley, Bert .

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2010, 2 (12) :a003178

[7]

Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1 [J].

Carroll, JS ;

Liu, XS ;

Brodsky, AS ;

Li, W ;

Meyer, CA ;

Szary, AJ ;

Eeckhoute, J ;

Shao, WL ;

Hestermann, EV ;

Geistlinger, TR ;

Fox, EA ;

Silver, PA ;

Brown, M .

CELL, 2005, 122 (01) :33-43

[8]

Targeting the androgen receptor pathway in prostate cancer [J].

Chen, Yu ;

Sawyers, Charles L. ;

Scher, Howard I. .

CURRENT OPINION IN PHARMACOLOGY, 2008, 8 (04) :440-448

[9]

Allosteric modulation of DNA by small molecules [J].

Chenoweth, David M. ;

Dervan, Peter B. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (32) :13175-13179

[10]

Chi KN, 2001, CLIN CANCER RES, V7, P3920

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