Co-operative transport by molecular motors

被引：21

作者：

Berger, Florian ^{[1
]}

Keller, Corina ^{[1
]}

Mueller, Melanie J. I. ^{[2
]}

Klumpp, Stefan ^{[1
]}

Lipowsky, Reinhard ^{[1
]}

机构：

[1] Max Planck Inst Colloids & Interfaces, D-14424 Potsdam, Germany

[2] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2011年 / 39卷

关键词：

bidirectional transport; co-operative transport; diffusive linker; molecular motor; stochastic modelling; tug-of-war; ACTIN-BASED TRANSPORT; TUG-OF-WAR; CARGO TRANSPORT; BIDIRECTIONAL TRANSPORT; KINESIN; MICROTUBULE; PROCESSIVITY; MECHANISM; MOTILITY; TETHERS;

D O I：

10.1042/BST0391211

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Intracellular transport is often driven co-operatively by several molecular motors, which may belong to one or several motor species. Understanding how these motors interact and what co-ordinates and regulates their movements is a central problem in studies of intracellular transport. A general theoretical framework for the analysis of such transport processes is described, which enables us to explain the behaviour of intracellular cargos by the transport properties of individual motors and their interactions. We review recent advances in the theoretical description of motor co-operativity and discuss related experimental results.

引用

页码：1211 / 1215

页数：5

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