Prolongation of life span associated with immunological modification by chronic low-dose-rate irradiation in MRL-lpr/lpr mice

被引：79

作者：

Ina, Y ^{[1
]}

Sakai, K ^{[1
]}

机构：

[1] Cent Res Inst Elect Power Ind, Low Dose Radiat Res Ctr, Tokyo 2018511, Japan

来源：

RADIATION RESEARCH | 2004年 / 161卷 / 02期

关键词：

D O I：

10.1667/RR3120

中图分类号：

Q [生物科学];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Chronic low-dose-rate 7 irradiation at 0.35 or 1.2 mGy/h prolonged the life span of MRL-lpr/lpr mice carrying a deletion in the apoptosis-regulating Fas gene that markedly shortens life due to severe autoimmune disease. Immunological modifications as indicated by a significant increase of CD8(+) T cells and a significant decrease of CD3(+) CD45R/B220(+) as well as CD45R/B220(+) CD40(+) cells were found in parallel with amelioration of total-body lymphadenopathy, splenomegaly, proteinuria, and kidney and brain syndromes. (C) 2004 by Radiation Research Society

引用

页码：168 / 173

页数：6

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