Understanding the role of dietary components on atherosclerosis using genetic engineered mouse models

被引：23

作者：

Sarria, AJ

Surra, JC

Acin, S

Carnicer, R

Navarro, MA

Arbones-Mainar, JM

Guillen, N

Martinez-Gracia, MV

Arnal, C

Osada, J

机构：

[1] Univ Zaragoza, Fac Med, Dept Bioquim & Biol Mol & Celular, E-50013 Zaragoza, Spain

[2] Univ Zaragoza, Fac Med, Dept Anim Patol, E-50013 Zaragoza, Spain

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2006年 / 11卷

关键词：

apolipoprotein E; knockout mice; deficient mice; atherosclerosis; diet; LDL receptor; review;

D O I：

10.2741/1852

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The generation by genetic engineering of two murine models to investigate atherosclerosis, such as the apoE- and LDLr- deficient mice, is providing an extraordinaire knowledge of the effect of different nutrients on this complex disease. The present revision provides a comprehensive overview of the advances in this field that point to a remarkable complexity. While some controversies over puzzling results could be explained invoking potential nutrient interactions or different food sources of nutrients, it also appears that other factors such as sex, genetic background or immunological status are emerging as generators of differential responses to nutrients during the atherosclerotic process.

引用

页码：955 / 967

页数：13

共 99 条

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