GABAA receptor subtypes underlying general anesthesia

被引：64

作者：

Bonin, Robert P. ^{[1
]}

Orser, Beverley A. ^{[1
,2
,3
]}

机构：

[1] Univ Toronto, Dept Physiol, Toronto, ON M5S 1A8, Canada

[2] Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A8, Canada

[3] Sunnybrook Hlth Sci Ctr, Dept Anesthesia, Toronto, ON M4N 3M5, Canada

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 2008年 / 90卷 / 01期

关键词：

anesthesia; GABA; GABA(A) receptors; GABA modulators; THIP; isoflurane; etomidate;

D O I：

10.1016/j.pbb.2007.12.011

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 [法学]; 0303 [社会学]; 030303 [人类学]; 04 [教育学]; 0402 [心理学];

摘要：

General anesthetics produce a constellation of behavioral responses and widespread neurodepression. Recent studies have implicated the gamma-aminobutyric acid (GABA) subtype A receptor as a primary anesthetic target. During the past decade, considerable progress has been made in dissecting the behavioral effects of anesthetics according to the subunit composition of GABA(A) receptors. In this review, we describe how particular GABA(A) receptor subtypes expressed in different brain regions are critical for the expression of behavioral endpoints, such as amnesia, sedation, and hypnosis. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：105 / 112

页数：8

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