Discovering genome regulation with 3C and 3C-related technologies

被引：30

作者：

Ethier, Sylvain D.

Miura, Hisashi

Dostie, Josee ^{[1
]}

机构：

[1] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2012年 / 1819卷 / 05期

基金：

加拿大健康研究院;

关键词：

Chromatin; Gene regulation; Chromosome conformation capture; Epigenetics; Transcription; NUCLEAR LAMINA INTERACTIONS; GENE-EXPRESSION; TRANSCRIPTION FACTORIES; CHROMATIN CONFORMATION; INTERACTIONS REVEALS; DNA METHYLATION; BINDING-SITES; CROSS-LINKING; CTCF; ORGANIZATION;

D O I：

10.1016/j.bbagrm.2011.12.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been known for some time that eukaryotic genomic DNA is packaged in the form of highly organized chromatin in vivo. This organization is important not only to reduce the length of chromosomes during interphase but also because it represents a type of higher-order genome regulation mechanism. Indeed, spatial chromatin architecture is known to be important for transcription, DNA replication and repair. Chromosome structure can be observed at different scales and studied with a variety of complementary techniques. For example, microscopy can provide single cell information while technologies such as the chromosome conformation capture (3C) method and its derivatives can yield higher-resolution data from cell populations. In this review, we report on the biological questions addressed with 3C and 3C-related techniques and what has been uncovered to date. We also explore what these methods may further reveal about the regulation of genomic DNA activities. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：401 / 410

页数：10

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