Strontium Ranelate Prevents Bone Loss in a Rat Model of Localized Muscle Paralysis

被引：10

作者：

Sheng, Zhi-Feng ^{[1
,2
]}

Ma, Yu-Lin ^{[3
]}

Tong, Dejun ^{[4
]}

Fang, De-Yu ^{[2
]}

Liang, Qing-Chun ^{[5
]}

Liu, Li-Hong ^{[6
]}

Zhang, Jian ^{[1
]}

Liao, Er-Yuan ^{[2
]}

机构：

[1] Hunan Normal Univ, Coll Life Sci, Key Lab Prot Chem & Dev Biol, Educ Minist China, Changsha, Hunan, Peoples R China

[2] Cent S Univ, Xiang Ya Hosp 2, Inst Metab & Endocrinol, Changsha 410011, Hunan, Peoples R China

[3] So Med Univ, Affiliated Xiaolan Hosp, Dept Endocrinol, Zhongshan, Peoples R China

[4] Cent S Univ, Xiang Ya Hosp 2, Dept Hosp Infect Management, Changsha 410011, Hunan, Peoples R China

[5] Cent S Univ, Xiang Ya Hosp 2, Dept Pathol, Changsha 410011, Hunan, Peoples R China

[6] Cent S Univ, Xiang Ya Hosp 2, Dept Orthoped, Changsha 410011, Hunan, Peoples R China

来源：

ANNALS OF BIOMEDICAL ENGINEERING | 2012年 / 40卷 / 03期

关键词：

Strontium ranelate; Osteoporosis; Rat; Immoblization; ZOLEDRONIC ACID; MINERAL DENSITY; DISUSE; IMMOBILIZATION; OSTEOPOROSIS; INHIBITION; STRENGTH; FRACTURE; ATROPHY;

D O I：

10.1007/s10439-011-0406-2

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Twenty-one 3.5-month-old female Sprague-Dawley rats were randomly assigned to three groups: BTX group, in which each rat received a single intramuscular injection of 2 U of Clostridium botulinum toxin (BTX) in the quadriceps femoris muscle of the right hind limb; BTX + SR group, in which each rat received a BTX injection and a dose of strontium ranelate (dose level of 625 mg/kg/day); and the control group. All the rats were killed at 9 weeks post-treatment. It was showed that BTX-induced rats a rapid loss of body weight in the first 3 weeks, after which their body weight showed a slow increase similar to that observed in the control rats. The net body weight loss was mainly attributed to muscle atrophy. BTX caused remarkable bone degradation in either the trabecular bone or the cortical bone of the disuse femur. The deteriorations in the bone mass and bone microstructure were locally limited and could be prevented by strontium ranelate treatment. Biomechanical analysis showed that strontium ranelate treatment improved the mechanical performance of the tibia in BTX-treated rats. It was showed that a clinical-corresponding dose of strontium ranelate could prevent bone loss in long-term immobilized rats.

引用

页码：657 / 665

页数：9

共 41 条

[1]

Strontium ranelate improves bone strength in ovariectomized rat by positively influencing bone resistance determinants [J].