Iron status in manganese alloy production workers

被引:31
作者
Ellingsen, DG
Haug, E
Ulvik, RJ
Thomassen, Y
机构
[1] Natl Inst Occupat Hlth, N-0033 Oslo, Norway
[2] Aker Univ Hosp, Hormone Lab, N-0514 Oslo, Norway
[3] Univ Bergen, Haukeland Hosp, Dept Clin Biochem, N-5021 Bergen, Norway
关键词
iron; manganese; soluble serum transferrin receptor; smoking;
D O I
10.1002/jat.913
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
The aim of this study was to investigate markers of iron status in production workers with current and long-term exposure to manganese (Mn) alloys. A total of 100 Mn-exposed male workers were compared with 100 male controls matched for age in a cross-sectional study. The geometric mean urinary Mn concentration in the exposed workers was 0.9 nmol mmol(-1) creatinine (range = 0.1-126.3), compared with 0.4 nmol mmol(-1) creatinine (range = 0.1-13.1) in the controls. The index group had been exposed to Mn for 20 years on average (range = 2.1-41.0). The geometric mean concentration of soluble transferrin receptor was lower in the exposed subjects than in the controls (2.2 vs 2.6 mg l(-1); P < 0.001) and the concentration was negatively associated with current exposure to 'soluble' Mn in the inhalable aerosol fraction and with current smoking habits. An association was found between the concentration of serum soluble transferrin receptor and the concentration of Mn in whole blood (Pearson's r = 0.48; P < 0.001) in the controls. The results suggest that Mn-exposed workers have higher intracellular iron concentration in the erythrocyte precursors than the controls, resulting in a down-regulation of transferrin receptors on the surface of these cells. The concentrations of Mn in the blood of occupationally non-exposed individuals appear to be influenced by iron status, even at physiological iron levels. Copyright (C) 2003 John Wiley Sons, Ltd.
引用
收藏
页码:239 / 247
页数:9
相关论文
共 35 条
[1]   MANGANESE TRANSPORT ACROSS THE BLOOD-BRAIN-BARRIER - RELATIONSHIP TO IRON HOMEOSTASIS [J].
ASCHNER, M ;
ASCHNER, JL .
BRAIN RESEARCH BULLETIN, 1990, 24 (06) :857-860
[2]   ON THE LIMITED ABILITY OF SUPEROXIDE TO RELEASE IRON FROM FERRITIN [J].
BOLANN, BJ ;
ULVIK, RJ .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1990, 193 (03) :899-904
[3]   DETERMINATION OF IRON STATUS - BRIEF REVIEW OF PHYSIOLOGICAL-EFFECTS ON IRON MEASURES [J].
BORCHIOHNSEN, B .
ANALYST, 1995, 120 (03) :891-893
[4]   INCORPORATION OF MANGANESE INTO ERYTHROCYTES AS EVIDENCE FOR A MANGANESE PORPHYRIN IN MAN [J].
BORG, DC ;
COTZIAS, GC .
NATURE, 1958, 182 (4650) :1677-1678
[5]  
Brittenham Gary M., 2000, Hematology Am Soc Hematol Educ Program, P39, DOI 10.1182/asheducation-2000.1.39
[6]   SERUM TRANSFERRIN RECEPTOR [J].
COOK, JD ;
SKIKNE, BS ;
BAYNES, RD .
ANNUAL REVIEW OF MEDICINE, 1993, 44 :63-74
[7]   Distribution of injected iron 59 and manganese 54 in hypotransferrinemic mice [J].
Dickinson, TK ;
Devenyi, AG ;
Connor, JR .
JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 1996, 128 (03) :270-278
[8]  
DIEZEWAL.M, 1968, P SOC EXP BIOL MED, V129, P448, DOI 10.3181/00379727-129-33341
[9]   Manganese air exposure assessment and biological monitoring in the manganese alloy production industry [J].
Ellingsen, DG ;
Hetland, SM ;
Thomassen, Y .
JOURNAL OF ENVIRONMENTAL MONITORING, 2003, 5 (01) :84-90
[10]   EFFECT OF HIGH DIETARY MANGANESE ON HEMOGLOBIN FORMATION [J].
HARTMAN, RH ;
MATRONE, G ;
WISE, GH .
JOURNAL OF NUTRITION, 1955, 57 (03) :429-439