Genetics and the variability of treatment response in asthma

被引：17

作者：

Israel, E ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Pulm & Crit Care Med, Boston, MA USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2005年 / 115卷 / 04期

关键词：

asthma; treatment response variability; pharmacogenomics; leukotrienes; beta-agonists;

D O I：

10.1016/j.jaci.2005.01.029

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 [免疫学];

摘要：

Pharmacogenetics is the study of how genetic differences influence the variability in patients' responses to therapy. Using specific examples in asthma, I will define the concepts of variability in response to therapy in asthma. I will then use the relationship between specific genetic polymorphisms and the response to beta-adrenergic agonists and leukotriene modifiers to illustrate pharmacogenetic interactions and to acquaint the reader with the applicability of these findings to clinical practice.

引用

页码：S532 / S538

页数：7

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