Maternal vitamin D deficiency alters the expression of genes involved in dopamine specification in the developing rat mesencephalon

被引：71

作者：

Cui, Xiaoying ^{[1
]}

Pelekanos, Matthew ^{[1
,2
]}

Burne, Thomas H. J. ^{[1
,2
,3
]}

McGrath, John J. ^{[1
,3
,4
]}

Eyles, Darryl W. ^{[1
,2
,3
]}

机构：

[1] Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia

[2] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia

[3] Queensland Ctr Mental Hlth Res, Wacol, Qld 4076, Australia

[4] Univ Queensland, Dept Psychiat, Brisbane, Qld 4072, Australia

来源：

NEUROSCIENCE LETTERS | 2010年 / 486卷 / 03期

基金：

英国医学研究理事会;

关键词：

Vitamin D; Schizophrenia; Nurr1; p57Kip2; Dopamine ontogeny; Animal model; IMMUNE ACTIVATION; RECEPTOR NURR1; ANIMAL-MODEL; CELL-CYCLE; ADULT-RAT; NGFI-B; SCHIZOPHRENIA; RISK; PREGNANCY; HYPERLOCOMOTION;

D O I：

10.1016/j.neulet.2010.09.057

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Schizophrenia is a neurodevelopment disorder that is strongly associated with alterations in dopamine neurotransmission Common features of animal models of schizophrenia include behavioural cognitive and/or pharmacological abnormalities reflective of aberrant DA signaling The aim of this study was to examine the expression of genes important for dopaminergic development and maturation within the embryonic mesencephalon using an epidemiologically-informed animal model of schizophrenia the developmental vitamin D (DVD) deficient rat model Two groups of female Sprague-Dawley rats were fed either a diet replete (1000 IU/kg) or deplete (0 IU/kg) of vitamin D mated and foetal mesencephalon collected at embryonic day (E) E12 or E15 Using real time-PCR the DVD-deficient embryos had a significant reduction in factors crucial in specifying dopaminergic phenotype such as Nurr1 and p57Kip2 No group differences were found for Lmx1b or Ptx3 Reductions in these specification factors may alter the ontogeny of DA neurons and may ultimately help to explain the behavioural abnormalities reported in adult offspring from this model (C) 2010 Elsevier Ireland Ltd All rights reserved

引用

页码：220 / 223

页数：4

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