Carbon monoxide neurotransmission activated by CK2 phosphorylation of heme oxygenase-2

被引:114
作者
Boehning, D
Moon, C
Sharma, S
Hurt, KJ
Hester, LD
Ronnett, GV
Shugar, D
Snyder, SH
机构
[1] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA
[3] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA
[4] Polish Acad Sci, Inst Biochem & Biophys, PL-02106 Warsaw, Poland
关键词
D O I
10.1016/S0896-6273(03)00596-8
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Carbon monoxide (CO) is a putative gaseous neurotransmitter that lacks vesicular storage and must be synthesized rapidly following neuronal depolarization. We show that the biosynthetic enzyme for CO, heme oxygenase-2 (HO2), is activated during neuronal stimulation by phosphorylation by CK2 (formerly casein kinase 2). Phorbol ester treatment of hippocampal cultures results in the phosphorylation and activation of HO2 by CK2, implicating protein kinase C (PKC) in CK2 stimulation. Odorant treatment of olfactory receptor neurons augments HO2 phosphorylation and activity as well as cyclic guanosine monophosphate (cGMP) levels, with all of these effects selectively blocked by CK2 inhibitors. Likewise, CO-mediated nonadrenergic, noncholinergic (NANC) relaxation of the internal anal sphincter requires CK2 activity. Our findings provide a molecular mechanism for the rapid neuronal activation of CO biosynthesis, as required for a gaseous neurotransmitter.
引用
收藏
页码:129 / 137
页数:9
相关论文
共 47 条
  • [1] Neural roles for heme oxygenase:: Contrasts to nitric oxide synthase
    Barañano, DE
    Snyder, SH
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (20) : 10996 - 11002
  • [2] A mammalian iron ATPase induced by iron
    Barañano, DE
    Wolosker, H
    Bae, BI
    Barrow, RK
    Snyder, SH
    Ferris, CD
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (20) : 15166 - 15173
  • [3] Heme oxygenase-2 distribution in anorectum: colocalization with neuronal nitric oxide synthase
    Battish, R
    Cao, GY
    Lynn, RB
    Chakder, S
    Rattan, S
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2000, 278 (01): : G148 - G155
  • [4] Casein kinase 2 as a potentially important enzyme in the nervous system
    Blanquet, PR
    [J]. PROGRESS IN NEUROBIOLOGY, 2000, 60 (03) : 211 - 246
  • [5] Blanquet PR, 2000, NEUROSCIENCE, V95, P705
  • [6] Neurotrophin-induced activation of casein kinase 2 in rat hippocampal slices
    Blanquet, PR
    [J]. NEUROSCIENCE, 1998, 86 (03) : 739 - 749
  • [7] NITRIC-OXIDE SYNTHASE PROTEIN AND MESSENGER-RNA ARE DISCRETELY LOCALIZED IN NEURONAL POPULATIONS OF THE MAMMALIAN CNS TOGETHER WITH NADPH DIAPHORASE
    BREDT, DS
    GLATT, CE
    HWANG, PM
    FOTUHI, M
    DAWSON, TM
    SNYDER, SH
    [J]. NEURON, 1991, 7 (04) : 615 - 624
  • [8] ISOLATION OF NITRIC-OXIDE SYNTHETASE, A CALMODULIN-REQUIRING ENZYME
    BREDT, DS
    SNYDER, SH
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (02) : 682 - 685
  • [9] PKC-ζ-associated CK2 participates in the turnover of free IκBα
    Bren, GD
    Pennington, KN
    Paya, CV
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 2000, 297 (05) : 1245 - 1258
  • [10] OPTIMIZED SURVIVAL OF HIPPOCAMPAL-NEURONS IN B27-SUPPLEMENTED NEUROBASAL(TM), A NEW SERUM-FREE MEDIUM COMBINATION
    BREWER, GJ
    TORRICELLI, JR
    EVEGE, EK
    PRICE, PJ
    [J]. JOURNAL OF NEUROSCIENCE RESEARCH, 1993, 35 (05) : 567 - 576