Systemic PCP treatment elevates brain extracellular 5-HT: a microdialysis study in awake rats

被引：95

作者：

Martin, P ^{[1
]}

Carlsson, ML ^{[1
]}

Hjorth, S ^{[1
]}

机构：

[1] Univ Gothenburg, Dept Pharmacol, S-40530 Gothenburg, Sweden

来源：

NEUROREPORT | 1998年 / 9卷 / 13期

关键词：

GABA; microdialysis; NMDA receptor antagonist; phencyclidine; rat; serotonin; schizophrenia;

D O I：

10.1097/00001756-199809140-00012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE NMDA receptor antagonist phencyclidine (PCP) has low micromolar affinity for the 5-HT reuptake site, but it is uncertain whether PCP blocks 5-HT reuptake when given systemically to rats in behaviourally stimulating doses. We here report for the first time that systemically administered PCP (5 mg/kg, s.c.) increases extracellular 5-HT levels in the rat medial prefrontal cortex (to 322%) and dorsal hippocampus (to 233%). Increases were found also when citalopram (1 mu M) was included in the perfusion medium (to 184 and 180%, respectively). Extracellular 5-HIAA concentrations increased during both conditions, and extracellular GABA decreased in the dorsal hippocampus. It is concluded that systemic PCP treatment elevates extracellular 5-HT levels, probably through mechanisms other than a blockade of 5-HT reuptake. NeuroReport 9: 2985-2988 (C) 1998 Lippincott Williams & Wilkins.

引用

页码：2985 / 2988

页数：4

共 27 条

[1] THE DISSOCIATIVE ANESTHETICS, KETAMINE AND PHENCYCLIDINE, SELECTIVELY REDUCE EXCITATION OF CENTRAL MAMMALIAN NEURONS BY N-METHYL-ASPARTATE [J].

ANIS, NA ;

BERRY, SC ;

BURTON, NR ;

LODGE, D .

BRITISH JOURNAL OF PHARMACOLOGY, 1983, 79 (02) :565-575

[2] INVITRO EFFECT OF PHENCYCLIDINE AND OTHER PSYCHOMOTOR STIMULANTS ON SEROTONIN UPTAKE IN HUMAN-PLATELETS [J].

ARORA, RC ;

MELTZER, HY .

LIFE SCIENCES, 1980, 27 (17) :1607-1613

[3] DIFFERENTIAL INHIBITION OF SEROTONIN RELEASE BY 5-HT AND NA REUPTAKE BLOCKERS AFTER SYSTEMIC ADMINISTRATION [J].

AUERBACH, SB ;

LUNDBERG, JF ;

HJORTH, S .

NEUROPHARMACOLOGY, 1995, 34 (01) :89-96

[4]

Bunney Blynn Garland, 1995, P1205

[5] SEROTONIN RELEASE ESTIMATED BY TRANSCORTICAL DIALYSIS IN FREELY-MOVING RATS [J].

CARBONI, E ;

DICHIARA, G .

NEUROSCIENCE, 1989, 32 (03) :637-645

[6] AMPHETAMINE, COCAINE, PHENCYCLIDINE AND NOMIFENSINE INCREASE EXTRACELLULAR DOPAMINE CONCENTRATIONS PREFERENTIALLY IN THE NUCLEUS ACCUMBENS OF FREELY MOVING RATS [J].

CARBONI, E ;

IMPERATO, A ;

PEREZZANI, L ;

DICHIARA, G .

NEUROSCIENCE, 1989, 28 (03) :653-661

[7] ANALYSIS OF EXTRACELLULAR DOPAC, HVA AND 5-HIAA IN RAT STRIATUM INVIVO BY DIFFERENTIAL PULSE VOLTAMMETRY - EFFECT OF PHENCYCLIDINE, HALOPERIDOL AND THEIR COADMINISTRATION [J].

CRESPI, F ;

KEANE, PE .

PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 1987, 19 (09) :639-649

[8] PHENCYCLIDINE (PCP) INJECTED IN THE NUCLEUS ACCUMBENS INCREASES EXTRACELLULAR DOPAMINE AND SEROTONIN AS MEASURED BY MICRODIALYSIS [J].

HERNANDEZ, L ;

AUERBACH, S ;

HOEBEL, BG .

LIFE SCIENCES, 1988, 42 (18) :1713-1723

[9]

HIRAMATSU M, 1989, EUR J PHARMACOL, V166, P359

[10] FURTHER EVIDENCE FOR THE IMPORTANCE OF 5-HT1A AUTORECEPTORS IN THE ACTION OF SELECTIVE SEROTONIN REUPTAKE INHIBITORS [J].

HJORTH, S ;

AUERBACH, SB .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1994, 260 (2-3) :251-255

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